SH3GL2 and GSTM3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL2	GSTM3
Description		SH3 domain containing GRB2 like 2, endophilin A1	glutathione S-transferase mu 3
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Nucleus Cytoplasm Cytosol Sperm Fibrous Sheath Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Glutathione Transferase Activity Protein Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Glutathione Metabolic Process Establishment Of Blood-nerve Barrier Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Response To Estrogen Cellular Detoxification Of Nitrogen Compound
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Glutathione conjugation
Drugs			Glutathione Glutathione disulfide Deoxycholic acid
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alcohol dependence ( 33290381) Blood protein levels ( 30072576)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	8 interacting genes: CLVS2 GSTM1 GSTM2 GSTM4 OGT SH3GL2 UCHL5 YWHAE
Entrez ID		6456	2947
HPRD ID		05125	00712
Ensembl ID		ENSG00000107295	ENSG00000134202
Uniprot IDs		Q99962	P21266 Q6FGJ9
PDB IDs		1X03 1X04 2D4C 2DBM	3GTU
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Nitrobenzene Metabolic Process Glutathione Binding Benzene-containing Compound Metabolic Process Xenobiotic Catabolic Process Glutathione Transferase Activity Long-chain Fatty Acid Biosynthetic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Metabolic Process Hepoxilin Biosynthetic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Fatty Acid Biosynthetic Process Calcium Channel Inhibitor Activity Enzyme Binding Modified Amino Acid Metabolic Process Catabolic Process Sulfur Compound Metabolic Process Carboxylic Acid Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fatty Acid Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Lipid Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Identical Protein Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Unsaturated Fatty Acid Metabolic Process Small Molecule Biosynthetic Process Regulation Of Heart Rate By Hormone Monocarboxylic Acid Metabolic Process Cellular Detoxification Lipid Biosynthetic Process Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Cytosol Transmembrane Transporter Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glutathione Derivative Biosynthetic Process Negative Regulation Of Proteolysis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Leukotriene-C4 Synthase Activity Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Calcium Ion Export Across Plasma Membrane
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