SH3GL2 and DNM1

Number of citations of the paper that reports this interaction (PubMedID 9238017)
36

Data Source:
HPRD (in vitro)

		SH3GL2	DNM1
Description		SH3 domain containing GRB2 like 2, endophilin A1	dynamin 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Cytoplasm Microtubule Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Cytoplasmic Vesicle Chromaffin Granule Cell Projection Synapse Extracellular Exosome Presynapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Hydrolase Activity GDP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Homooligomerization Protein Homotetramerization Regulation Of Vesicle Size Clathrin Coat Assembly Involved In Endocytosis Vesicle Scission
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	53 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNMBP DYRK1A EPS15 FILNC1 FNBP1 FTCD GRB2 GRIN1 GRIN2D HSPA13 ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PCNT PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PLK2 PRKCA PRNP RACK1 RNF10 SH3GL1 SH3GL2 SH3GL3 SNAP25 SNCA SNX9 SRC SUMO1 TIMM50 UBE2I
Entrez ID		6456	1759
HPRD ID		05125	03851
Ensembl ID		ENSG00000107295	ENSG00000106976
Uniprot IDs		Q99962	A0A994J7J4 B4DK06 B7ZAC0 Q05193
PDB IDs		1X03 1X04 2D4C 2DBM	1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A 7AX3 8SXZ 8SZ4 8SZ7 8SZ8 8T0K 8T0R 8TYM 8TYN
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Endocytosis Import Into Cell Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Presynaptic Endocytosis Glutamatergic Synapse Cytoplasm Lipid Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Cellular Component Biogenesis Cytosol Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Polymerization Perinuclear Region Of Cytoplasm Presynapse Cellular Component Assembly Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Plasma Membrane Plasma Membrane Tubulation Clathrin-coated Pit Phospholipid Binding Regulation Of Actin Filament Polymerization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Regulation Of Synaptic Plasticity Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Regulation Of Calcium Ion Transport Cadherin Binding Neurotrophin TRKA Receptor Binding Regulation Of Cytoskeleton Organization Synapse Negative Regulation Of Transport Long-term Synaptic Potentiation Regulation Of Signaling Regulation Of Apoptotic Process
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