SH3GL2 and SLC17A7

Number of citations of the paper that reports this interaction (PubMedID 16606361)
0

Data Source:
HPRD (in vitro, two hybrid)

		SH3GL2	SLC17A7
Description		SH3 domain containing GRB2 like 2, endophilin A1	solute carrier family 17 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Neuron Projection Cerebellar Mossy Fiber Synapse Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Glutamate Transport Vesicle Membrane Postsynapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Chloride Channel Activity L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Extracellularly Glutamate-gated Chloride Channel Activity Secondary Active Transmembrane Transporter Activity Symporter Activity Antiporter Activity Potassium:proton Antiporter Activity Transmembrane Transporter Activity Phosphate Ion Uniporter Activity L-glutamate Uniporter Activity
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Neural Retina Development Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Phosphate Ion Transport Chloride Transport Neurotransmitter Transport Chemical Synaptic Transmission Long-term Memory L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport Regulation Of Synapse Structure Or Activity Establishment Of Localization In Cell L-glutamate Import Phosphate Ion Homeostasis Transmembrane Transport Excitatory Postsynaptic Potential Potassium Ion Transmembrane Transport Synaptic Vesicle Lumen Acidification Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Synaptic Vesicle Endocytosis Chloride Transmembrane Transport
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Glutamate Neurotransmitter Release Cycle SLC-mediated transport of neurotransmitters
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	1 interacting genes: SH3GL2
Entrez ID		6456	57030
HPRD ID		05125	05551
Ensembl ID		ENSG00000107295	ENSG00000104888
Uniprot IDs		Q99962	Q9P2U7
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Postsynaptic Cytoskeleton Organization Regulation Of Blood-brain Barrier Permeability Dendrite Extension Presynaptic Cytosol Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Blood-brain Barrier Permeability Photoreceptor Ribbon Synapse Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal Base-excision Repair, AP Site Formation Single Strand Break Repair Ribosomal Small Subunit Binding Uracil DNA N-glycosylase Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination DNA Modification Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Pyrimidine-containing Compound Catabolic Process Negative Regulation Of ERBB Signaling Pathway Somatic Recombination Of Immunoglobulin Gene Segments Presynaptic Endocytosis Response To Nerve Growth Factor Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus Deoxyribonucleotide Metabolic Process Base-excision Repair Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Regulation Of Vascular Permeability Pyrimidine Nucleotide Metabolic Process B Cell Activation Involved In Immune Response Damaged DNA Binding Clathrin-coated Endocytic Vesicle Membrane Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Pyrimidine-containing Compound Metabolic Process Regulation Of Receptor Internalization Neuron Projection Extension Vesicle-mediated Transport In Synapse Nucleotide Catabolic Process Regulation Of Receptor-mediated Endocytosis
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