SH3GL2 and SLC17A7

Number of citations of the paper that reports this interaction (PMID 16606361)
10

Data Source:
HPRD (two hybrid, in vitro)

		SH3GL2	SLC17A7
Gene Name		SH3-domain GRB2-like 2	solute carrier family 17 (vesicular glutamate transporter), member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Cerebellar Mossy Fiber Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Glutamate Transport Vesicle Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	L-glutamate Transmembrane Transporter Activity Inorganic Phosphate Transmembrane Transporter Activity Sodium:inorganic Phosphate Symporter Activity Sodium-dependent Phosphate Transmembrane Transporter Activity
	Biological Process	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization	Ion Transport Phosphate Ion Transport Synaptic Transmission Neurotransmitter Secretion Long-term Memory Glutamate Secretion Synaptic Transmission, Glutamatergic Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sequestering Of Neurotransmitter Sodium-dependent Phosphate Transport L-glutamate Import Transmembrane Transport Regulation Of Excitatory Postsynaptic Membrane Potential L-glutamate Transmembrane Transport
Pathways		Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System	Organic anion transporters Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	1 interactors: SH3GL2
Entrez ID		6456	57030
HPRD ID		05125	05551
Ensembl ID		ENSG00000107295	ENSG00000104888
Uniprot IDs		B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962	B4DG46 Q9P2U7
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process	Regulation Of Receptor Internalization Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Establishment Of Vesicle Localization Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Establishment Of Organelle Localization
Tagcloud ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	24days 3months abnormalities accordingly ages autism behavioral concordance cortex dams deficits disc1 elicited epigenetic exposed gria1 h4 hypoacetylation juvenile lysine ntrk3 offspring polyi pregnant psychiatric resemble robust schizophrenia utero
Tagcloud (Difference) ?		250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation	24days 3months abnormalities accordingly ages autism behavioral concordance cortex dams deficits disc1 elicited epigenetic exposed gria1 h4 hypoacetylation juvenile lysine ntrk3 offspring polyi pregnant psychiatric resemble robust schizophrenia utero
Tagcloud (Intersection) ?