SH3GL2 and PPP1R21

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL2	PPP1R21
Description		SH3 domain containing GRB2 like 2, endophilin A1	protein phosphatase 1 regulatory subunit 21
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Endosome Early Endosome Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	RNA Binding MRNA Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Regulation Of Intracellular MRNA Localization
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Chronotype ( 30696823) Colorectal cancer ( 30529582) Educational attainment ( 27046643) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 29403010) Prudent dietary pattern ( 28644415) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	6 interacting genes: CFTR FBXO7 MTNR1B SH2D2A SH3GL2 ZDHHC17
Entrez ID		6456	129285
HPRD ID		05125	17294
Ensembl ID		ENSG00000107295	ENSG00000162869
Uniprot IDs		Q99962	Q6ZMI0
PDB IDs		1X03 1X04 2D4C 2DBM	7ND2
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Golgi-associated Vesicle Membrane Regulation Of Cell Communication Clathrin-coated Endocytic Vesicle Membrane Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Developmental Process Regulation Of Intracellular Signal Transduction Synapse Regulation Of ERBB Signaling Pathway Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Anion Channel Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Blood-brain Barrier Permeability Glutamatergic Synapse Lewy Body Core Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Biological Quality Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction Regulation Of Neuronal Action Potential Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Neuron Apoptotic Process Photoreceptor Ribbon Synapse
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