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SH3GL2 and LRRK2
Number of citations of the paper that reports this interaction (PubMedID
22998870
)
0
Data Source:
BioGRID
(enzymatic study)
SH3GL2
LRRK2
Description
SH3 domain containing GRB2 like 2, endophilin A1
leucine rich repeat kinase 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cell Projection
Synapse
Perinuclear Region Of Cytoplasm
Photoreceptor Ribbon Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Presynaptic Cytosol
Golgi Membrane
Extracellular Space
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Cytoskeleton
Plasma Membrane
Microvillus
Synaptic Vesicle
Membrane
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Ciliary Basal Body
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Amphisome
Autolysosome
Membrane Raft
Synapse
Phagocytic Vesicle
Intracellular Organelle Lumen
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Molecular Function
Protein Binding
Lipid Binding
Identical Protein Binding
SNARE Binding
Nucleotide Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Transferase Activity
Hydrolase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Beta-catenin Destruction Complex Binding
Biological Process
Regulation Of Receptor Internalization
Endocytosis
Signal Transduction
Central Nervous System Development
Negative Regulation Of Gene Expression
Neuron Projection Development
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of MAPK Cascade
Synaptic Vesicle Endocytosis
Dendrite Extension
Postsynaptic Actin Cytoskeleton Organization
Negative Regulation Of Blood-brain Barrier Permeability
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
MAPK Cascade
Protein Phosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Cell Surface Receptor Signaling Pathway
JNK Cascade
Rho Protein Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Intracellular Protein Localization
Determination Of Adult Lifespan
Cellular Response To Starvation
Anatomical Structure Morphogenesis
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Autophagy
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Vesicle-mediated Transport
Negative Regulation Of Macroautophagy
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Cell Differentiation
Regulation Of Proteolysis
Neuron Differentiation
Regulation Of Cell Projection Organization
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Regulation Of SNARE Complex Assembly
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAPK Cascade
Negative Regulation Of Notch Signaling Pathway
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Animal Organ Development
Neuron Projection Morphogenesis
Modulation Of Chemical Synaptic Transmission
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Metabolic Process
Mitochondrion Localization
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Vesicle-mediated Transport
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Cellular Response To Manganese Ion
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Regulation Of CAMP/PKA Signal Transduction
Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Intracellular Signal Transduction
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Cellular Response To Curcumin
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
EGFR downregulation
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
PTK6 promotes HIF1A stabilization
Drugs
Fostamatinib
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Cerebral cortical growth (
29682794
)
Cognitive performance (
19734545
)
FEV1 (
30804560
)
HDL cholesterol levels in HIV infection (
33109212
)
Heart failure (
20445134
)
Lung function (FVC) (
30804560
)
Midgestational circulating levels of PBDEs (
28235828
)
Multiple sclerosis (
19010793
)
Myopia (
27182965
)
Nontraumatic osteonecrosis of the femoral head (
32701715
)
Obesity-related traits (
23251661
)
Obsessive-compulsive traits (
33531474
)
Parkinson's disease (
22451204
32201043
28892059
27182965
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pursuit maintenance gain (
29064472
)
Small cell lung carcinoma (
28604730
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
28067908
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
23128233
28067908
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
19915576
31660654
28892059
28011712
27182965
25064009
24842889
22438815
21738487
21292315
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
53 interacting genes:
ACTG1
ADAM15
ADAM19
ADRB1
AMPH
APP
ARNT2
ATXN2
BIN1
CD2AP
CLEC3B
DACT1
DLGAP4
DNM1
DNM2
DPPA4
DPYSL4
EGFL6
EMD
ERH
F13A1
FBXO32
FXR1
GCH1
GSTM3
HLA-DQA1
IGHM
IL6
ITCH
ITSN1
LCP2
LRRK2
MAP4K3
MAST2
PAK2
PAXIP1
PDCD6IP
PPP1R21
PPP6R1
PRR14
SH3GL3
SH3KBP1
SHANK3
SLC17A7
SYNJ1
TCEA2
TERF1
TIAM2
TMEM108
TYMS
ZNF219
ZNF580
ZXDC
143 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
ARK2N
AURKB
BAG1
BAG2
BAG3
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
Entrez ID
6456
120892
HPRD ID
05125
10613
Ensembl ID
ENSG00000107295
ENSG00000188906
Uniprot IDs
Q99962
Q17RV3
Q5S007
PDB IDs
1X03
1X04
2D4C
2DBM
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XAF
6XR4
7LHT
7LHW
7LI3
7LI4
7THY
7THZ
8FO2
8FO7
8FO8
8FO9
8SMC
8TXZ
8TYQ
8TZB
8TZC
8TZE
8TZF
8TZG
8TZH
8U1B
8U7H
8U7L
8U8A
8U8B
8VH4
8VH5
9C61
9C76
9CHO
Enriched GO Terms of Interacting Partners
?
Endocytosis
Synapse
Neuron Projection
Import Into Cell
SH3 Domain Binding
Endosome
Regulation Of Endocytosis
Regulation Of Cellular Component Organization
Synaptic Vesicle Endocytosis
Vesicle Scission
Presynaptic Endocytosis
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Vesicle-mediated Transport
Cytoplasmic Vesicle
Glutamatergic Synapse
Positive Regulation Of Immune System Process
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Long-term Neuronal Synaptic Plasticity
Growth Cone
Clathrin-coated Pit
Cell Junction Organization
Presynapse
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Regulation Of Synaptic Vesicle Recycling
Positive Regulation Of Multicellular Organismal Process
Regulation Of Synapse Structure Or Activity
Maintenance Of Blood-brain Barrier
Vesicle-mediated Transport
Vesicle-mediated Transport In Synapse
Clathrin Binding
Receptor-mediated Endocytosis
Axon
Cerebellar Mossy Fiber
Developmental Process
Regulation Of Long-term Synaptic Potentiation
Cellular Response To Manganese Ion
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Membrane Potential
Cell-cell Junction
Early Endosome
Regulation Of Nervous System Process
Nuclear Envelope Lumen
Cytoplasm
Tight Junction Assembly
Regulation Of Protein Metabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
Tight Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Developmental Process
Synaptic Vesicle
Protein Serine Kinase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Protein Kinase Binding
Cytosol
Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Cellular Response To Stress
Regulation Of Cellular Component Organization
Positive Regulation Of Protein Localization
Apoptotic Process
MAP Kinase Kinase Activity
Signal Transduction
Cytoplasm
Programmed Cell Death
Frizzled Binding
Cell Death
Positive Regulation Of Catabolic Process
Positive Regulation Of JNK Cascade
Macromolecule Metabolic Process
Positive Regulation Of Neuron Projection Arborization
Nucleotide Binding
ATP Binding
Protein Phosphorylation
Regulation Of JNK Cascade
Regulation Of Protein Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Projection Organization
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Apoptotic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteolysis
Developmental Cell Growth
JUN Kinase Kinase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Catabolic Process
Neuron Projection Extension
Cellular Response To Topologically Incorrect Protein
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Import Into Nucleus
Response To Light Stimulus
Regulation Of Protein Modification Process
Regulation Of Proteolysis
Phosphorylation
Response To Radiation
Protein Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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