SPTAN1 and FANCC

Number of citations of the paper that reports this interaction (PMID 10551855)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SPTAN1	FANCC
Gene Name		spectrin, alpha, non-erythrocytic 1	Fanconi anemia, complementation group C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Protein Complex Assembly Germ Cell Development Removal Of Superoxide Radicals
Pathways		Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth	Fanconi Anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4	27 interactors: ATP6 AZIN1 CAPN10 CDK1 DNAJB1 FANCA FANCD2 FANCE FANCF FANCG GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRT1 POR RPL18 RPS3A SPTA1 SPTAN1 STAT1 TCERG1 USP14 ZBTB32
Entrez ID		6709	2176
HPRD ID		01684	01967
Ensembl ID		ENSG00000197694	ENSG00000158169
Uniprot IDs		Q13813	B4E3W2 Q00597
PDB IDs		2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus	Protein Refolding Response To Unfolded Protein Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Stress Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA Repair Response To Stimulus Protein Import Into Mitochondrial Outer Membrane Response To Heat Protein Folding Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Membrane Organization Cellular Metabolic Process Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Axon Guidance Response To Oxidative Stress Response To External Stimulus Chaperone-mediated Protein Complex Assembly DNA Metabolic Process Establishment Of Protein Localization To Membrane Nucleobase-containing Compound Metabolic Process Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Apoptotic Process Cellular Response To Organonitrogen Compound Regulation Of Inclusion Body Assembly Regulation Of Cell Death Protein Localization To Organelle Female Gonad Development Axonogenesis Development Of Primary Female Sexual Characteristics Cellular Macromolecule Catabolic Process Viral Process Cellular Response To Peptide Hormone Stimulus Axon Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Peptide Nitric Oxide Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Metabolic Process
Tagcloud ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands	1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally
Tagcloud (Difference) ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands	1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally
Tagcloud (Intersection) ?