SPTAN1 and DDX24

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPTAN1	DDX24
Description		spectrin alpha, non-erythrocytic 1	DEAD-box helicase 24
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleus Nucleolus Cytoplasm Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Actin Cytoskeleton Organization Actin Filament Capping	RNA Metabolic Process
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333	37 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD FILNC1 GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 RNF10 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I USP7 VDAC3
Entrez ID		6709	57062
HPRD ID		01684	05860
Ensembl ID		ENSG00000197694	ENSG00000089737
Uniprot IDs		A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813	Q9GZR7
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite	RNA-templated DNA Biosynthetic Process Shelterin Complex Cellular Component Assembly Nuclear Body Regulation Of Protein Stability Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Capping Regulation Of Cellular Component Organization PML Body Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Organelle Organization Protein Localization To Organelle Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Telomere Maintenance Via Telomerase P53 Binding Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Cell Communication Protein-containing Complex Regulation Of Signaling Regulation Of Organelle Organization Telomeric DNA Binding Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process Nucleoplasm Regulation Of Cell Cycle Telomere Maintenance Receptor Serine/threonine Kinase Binding Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Negative Regulation Of Small Molecule Metabolic Process
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