SPTAN1 and EPB42

Number of citations of the paper that reports this interaction (PMID 12049649)
4

Data Source:
HPRD (in vitro)

		SPTAN1	EPB42
Gene Name		spectrin, alpha, non-erythrocytic 1	erythrocyte membrane protein band 4.2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Cytoskeleton Plasma Membrane Cortical Cytoskeleton
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping	Cell Morphogenesis Regulation Of Cell Shape Peptide Cross-linking Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Iron Ion Homeostasis
Pathways		Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4	13 interactors: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		6709	2038
HPRD ID		01684	01517
Ensembl ID		ENSG00000197694	ENSG00000166947
Uniprot IDs		Q13813	F5H563 P16452
PDB IDs		2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus	Movement Of Cell Or Subcellular Component Chemotaxis Locomotion Axon Guidance Neuron Projection Development Blood Coagulation Hemostasis Neuron Development Bicarbonate Transport Axonogenesis Cell Morphogenesis Ion Homeostasis Axon Development Cell Development Regulation Of Body Fluid Levels Response To External Stimulus Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Protein Targeting To Plasma Membrane Wound Healing Erythrocyte Development Cell Projection Organization Regulation Of Intracellular PH Myeloid Cell Differentiation Regulation Of Cellular PH Neuron Projection Morphogenesis Actin Filament Capping Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Actin Filament Depolymerization Homeostatic Process Organelle Organization P38MAPK Cascade Positive Regulation Of Platelet Aggregation Protein Localization To T-tubule Muscle Cell Differentiation Vesicle-mediated Transport Regulation Of PH Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Establishment Of Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Cell Differentiation Chemical Homeostasis Cell Part Morphogenesis Generation Of Neurons Negative Regulation Of Protein Polymerization Protein Stabilization Protein Secretion By Platelet
Tagcloud ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly
Tagcloud (Difference) ?		adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands	aplastic cbc cholelithiasis corpuscular crisis deformability dimax ektacytometry entails folic fragility hemolytic hemolyze hgb immunizations instituted mchc omin osmolality promptly repleted reticulocytes reticulocytosis sib sibs spherocytes spherocytosis splenectomy splenomegaly
Tagcloud (Intersection) ?