SPTAN1 and ZNF333

Number of citations of the paper that reports this interaction (PubMedID 17607528)
56

Data Source:
BioGRID (two hybrid)

		SPTAN1	ZNF333
Description		spectrin alpha, non-erythrocytic 1	zinc finger protein 333
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleus
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Actin Cytoskeleton Organization Actin Filament Capping	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Generic Transcription Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Platelet distribution width ( 32888494) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333	5 interacting genes: KDM1A SPTAN1 TRIM55 TRIM63 ZDHHC17
Entrez ID		6709	84449
HPRD ID		01684	15776
Ensembl ID		ENSG00000197694	ENSG00000160961
Uniprot IDs		A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813	B3KSN8 Q96JL9
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite	Protein Modification Process Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Cellular Component Size Response To Fungicide MRF Binding Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Spectrin Muscle Atrophy Histone H3K9 Demethylase Activity Purine Nucleobase Metabolic Process Positive Regulation Of Cell Size Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone Demethylase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Repair Complex Protein Metabolic Process Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Ubiquitin Protein Ligase Activity Microtubule Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Glycolytic Process Titin Binding Contractile Muscle Fiber
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