SPTAN1 and KALRN

Number of citations of the paper that reports this interaction (PubMedID 17607528)
56

Data Source:
BioGRID (two hybrid)

		SPTAN1	KALRN
Description		spectrin alpha, non-erythrocytic 1	kalirin RhoGEF kinase
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Actin Cytoskeleton Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Actin Cytoskeleton Organization Actin Filament Capping	Protein Phosphorylation Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	NRAGE signals death through JNK EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling RHOA GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 31959993 29785010 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte count ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 27863252 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)
Interacting Genes		60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333	22 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DSCAM DSCR9 DTNBP1 ENO3 EPHB2 FASLG GFI1B GRIK1 LNX1 MORC3 NDEL1 NRIP1 PAM PCNT SPTAN1 SUMO2 SUMO3
Entrez ID		6709	8997
HPRD ID		01684	06859
Ensembl ID		ENSG00000197694	ENSG00000160145
Uniprot IDs		A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813	A0A804HI91 A0A804HIN3 A0A804HKJ7 A0A804HKT9 C9IZQ6 O60229
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH	5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 8C7D
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite	Hippocampal Mossy Fiber To CA3 Synapse Radial Glia-guided Pyramidal Neuron Migration Regulation Of Dendritic Spine Development Nervous System Development Axon Dendritic Spine Development Regulation Of Synaptic Transmission, Glutamatergic Protein Tag Activity Regulation Of Neuron Projection Development Modulation Of Chemical Synaptic Transmission Cell Projection Morphogenesis Neuron Projection Morphogenesis Microtubule Organizing Center PML Body Cerebral Cortex Radially Oriented Cell Migration Ubiquitin-like Protein Ligase Binding Nuclear Matrix Microtubule Nucleation Cerebral Cortex Cell Migration Regulation Of Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Postsynapse Organization Neuronal Cell Body Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Neuron Recognition System Development Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Dendritic Spine Morphogenesis Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Cytoskeleton Organization Ovarian Follicle Rupture Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Vesicle Transport Along Microtubule Dendrite Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Amyloid-beta Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Cell Projection Organization Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Peptide Amidation
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