SPTAN1 and PSMG1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SPTAN1	PSMG1
Description		spectrin alpha, non-erythrocytic 1	proteasome assembly chaperone 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Protein Folding Chaperone Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	Actin Cytoskeleton Organization Actin Filament Capping	Cerebellar Granule Cell Precursor Proliferation Proteasome Assembly Chaperone-mediated Protein Complex Assembly Proteasome Core Complex Assembly
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Proteasome assembly Proteasome assembly
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Alanine aminotransferase levels ( 33547301) Ankylosing spondylitis ( 20062062) C-reactive protein levels ( 21300955) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) Eye morphology ( 29921221) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Inflammatory bowel disease ( 18758464) Pediatric autoimmune diseases ( 26301688) Primary sclerosing cholangitis ( 27992413 23603763) Serum alkaline phosphatase levels ( 33547301) Takayasu arteritis ( 23830517) Triglyceride levels ( 32203549) Ulcerative colitis ( 20228799)
Interacting Genes		60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333	10 interacting genes: BRCA1 CEBPA CSDE1 PRKAR1A PRKAR1B PSMG2 SNRNP70 SPTAN1 UBE2A YME1L1
Entrez ID		6709	8624
HPRD ID		01684	05598
Ensembl ID		ENSG00000197694	ENSG00000183527
Uniprot IDs		A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813	O95456
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH	8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8YIX 8YIY 8YIZ
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Cellular Response To Tumor Necrosis Factor Protein Kinase A Catalytic Subunit Binding Response To Tumor Necrosis Factor CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Postreplication Repair Cellular Response To Cytokine Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of CAMP/PKA Signal Transduction Multivesicular Body Ciliary Base RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Iduronate-2-sulfatase Activity
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