EDA2R and STRIT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EDA2R	STRIT1
Description		ectodysplasin A2 receptor	small transmembrane regulator of ion transport 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity	Protein Binding Enzyme Activator Activity
	Biological Process	Epidermis Development Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Calcium Ion Import Positive Regulation Of Cardiac Muscle Cell Contraction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Balding ( 26926045) Male-pattern baldness ( 22032556 27182965 28196072)
Interacting Genes		16 interacting genes: AGR3 ATP6V0C C1QB CASP8 CATSPERH CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 TRAF3 TRAF6	47 interacting genes: ANK1 ANKS6 AQP12B AQP6 ARL13B BIK BSCL2 BTN2A1 CD53 CD69 CD79A CMTM2 EDA2R ERGIC3 F11R FAM209A FFAR2 FXYD3 GOLM1 GPR42 GPR61 HSD17B11 HSD17B13 IFNGR2 ISLR2 JPH1 KCNJ6 KCNK5 MFF MOG MSMO1 MTIF3 PDZK1IP1 PI16 SCN3B SLC14A1 SLC34A2 SLC35H1 SLC38A1 SPNS3 STX1A STX2 TM4SF18 TMEM101 TMEM237 TMEM51 TSPAN15
Entrez ID		60401	100507537
HPRD ID		02230
Ensembl ID		ENSG00000131080	ENSG00000240045
Uniprot IDs		B2RBZ9 B4DQY6 Q9HAV5	P0DN84
PDB IDs			7MPA
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Death Receptor Binding Defense Response Death Effector Domain Binding Response To External Biotic Stimulus Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Myeloid Leukocyte Differentiation Death-inducing Signaling Complex Leukocyte Differentiation Regulation Of Proteolysis Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Signaling Adaptor Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Myeloid Cell Differentiation Positive Regulation Of Macrophage Differentiation Endosome Membrane Negative Regulation Of Necroptotic Process Positive Regulation Of Myeloid Cell Differentiation Cytoplasmic Side Of Plasma Membrane Immune System Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Response To Stress Regulation Of Myeloid Leukocyte Differentiation Mononuclear Cell Differentiation Tube Formation Regulation Of Macrophage Differentiation Innate Immune Response Granulocyte Differentiation Regulation Of Necroptotic Process Response To Other Organism Defense Response To Symbiont Regulation Of Programmed Necrotic Cell Death Cytokine-mediated Signaling Pathway Defense Response To Other Organism Immune Response Toll-like Receptor 4 Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Innate Immune Response Macrophage Differentiation Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation	Membrane Plasma Membrane Protein Binding Protein Localization To Membrane Steroid Dehydrogenase Activity Transmembrane Transport Water Transport Fluid Transport Protein Localization To Cell Periphery
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