EDA2R and FADD

Number of citations of the paper that reports this interaction (PMID 15280356)
3

Data Source:
HPRD (in vitro)

		EDA2R	FADD
Gene Name		ectodysplasin A2 receptor	Fas (TNFRSF6)-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Integral Component Of Membrane	Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein Complex Binding Tumor Necrosis Factor Receptor Superfamily Binding Death Effector Domain Binding Identical Protein Binding
	Biological Process	Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Positive Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Thymus Development Protein Heterooligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Regulation by c-FLIP Caspase-8 activation by cleavage Death Receptor Signalling Dimerization of procaspase-8 TRAIL signaling TRIF-mediated TLR3/TLR4 signaling FasL/ CD95L signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS		Male-pattern baldness ( 22032556)
Protein-Protein Interactions		7 interactors: C1QB CASP8 CEBPE EDA FADD TRAF3 TRAF6	45 interactors: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP SPOP STAT1 SUMO1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5
Entrez ID		60401	8772
HPRD ID		02230	03909
Ensembl ID		ENSG00000131080	ENSG00000168040
Uniprot IDs		B2RBZ9 E7EUS4 Q9HAV5	Q13158
PDB IDs			1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune Response TRAIL-activated Apoptotic Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Innate Immune Response Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Leukocyte Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Myeloid Leukocyte Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Regulation Of Immune System Process Macrophage Differentiation Tube Formation Regulation Of Myeloid Cell Differentiation Hemopoiesis Regulation Of Necrotic Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Immune System Development Organ Development Response To Other Organism Response To Biotic Stimulus Myeloid Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Regulation Of T Cell Apoptotic Process Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Peptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Zymogen Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Endopeptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Protein Processing Regulation Of Proteolysis Negative Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Activation Of Protein Kinase Activity
Tagcloud ?		admixture africans await breed ce compositionally deflate edar fst gujarati hemizygous herc2 homozygosity initio lct maasai mathematically organised phylogeography pigmentation prioritised proxy relatedness remodeler runs scmh1 slc24a5 sliding visualise	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		admixture africans await breed ce compositionally deflate edar fst gujarati hemizygous herc2 homozygosity initio lct maasai mathematically organised phylogeography pigmentation prioritised proxy relatedness remodeler runs scmh1 slc24a5 sliding visualise	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?