SDC4 and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDC4	SGTB
Description		syndecan 4	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Costamere Lysosomal Lumen Extracellular Exosome	Membrane TRC Complex
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Malaria ( 31844061) Psoriasis ( 20953189)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: CASK CCL5 CXCR4 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		6385	54557
HPRD ID		08366	18049
Ensembl ID		ENSG00000124145	ENSG00000197860
Uniprot IDs		B4E1S6 P31431	Q96EQ0
PDB IDs		1EJP 1EJQ 1OBY 1YBO 8BLV
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition TRC Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Protein Kinase C Signaling Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transport Signal Transduction Regulation Of Smooth Muscle Cell Proliferation Intracellular Signaling Cassette Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Response To Stress Locomotion Cell Migration Regulation Of Response To Wounding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Leukocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Developmental Process Schmidt-Lanterman Incisure Regulation Of Proteolysis Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Wound Healing Regulation Of Cell Projection Organization	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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