SDC4 and TANK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SDC4	TANK
Description		syndecan 4	TRAF family member associated NFKB activator
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Costamere Lysosomal Lumen Extracellular Exosome	Cytoplasm Cytosol Protein-containing Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity
	Biological Process	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS		Malaria ( 31844061) Psoriasis ( 20953189)	Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)
Interacting Genes		19 interacting genes: CASK CCL5 CXCR4 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC	32 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 WEE2-AS1 ZC3H12A
Entrez ID		6385	10010
HPRD ID		08366	04870
Ensembl ID		ENSG00000124145	ENSG00000136560
Uniprot IDs		B4E1S6 P31431	B2R7S3 Q6NW12 Q92844
PDB IDs		1EJP 1EJQ 1OBY 1YBO 8BLV	1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition TRC Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Protein Kinase C Signaling Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transport Signal Transduction Regulation Of Smooth Muscle Cell Proliferation Intracellular Signaling Cassette Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Response To Stress Locomotion Cell Migration Regulation Of Response To Wounding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Leukocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Developmental Process Schmidt-Lanterman Incisure Regulation Of Proteolysis Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Wound Healing Regulation Of Cell Projection Organization	CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Immune Response Response To Virus Intracellular Signaling Cassette Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction IkappaB Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Signal Transduction Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Communication Response To Other Organism Regulation Of Signaling Immune Response-regulating Signaling Pathway Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Defense Response Positive Regulation Of Gene Expression Regulation Of Type I Interferon Production IkappaB Kinase Complex Regulation Of Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Tumor Necrosis Factor Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To External Biotic Stimulus Signaling Adaptor Activity Positive Regulation Of Signal Transduction Immune System Process Pattern Recognition Receptor Signaling Pathway CD40 Signaling Pathway
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