SDC4 and SDCBP

Number of citations of the paper that reports this interaction (PMID 12241528)
28

Data Source:
HPRD (in vivo)

		SDC4	SDCBP
Gene Name		syndecan 4	syndecan binding protein (syntenin)
Image
Gene Ontology Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Vesicle Melanosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Thrombospondin Receptor Activity	Glycoprotein Binding Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Protein C-terminus Binding Cytoskeletal Adaptor Activity Growth Factor Binding Neurexin Family Protein Binding Identical Protein Binding Protein Homodimerization Activity Syndecan Binding Ephrin Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding Cell Adhesion Molecule Binding
	Biological Process	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly	Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Ephrin signaling Axon guidance Neurofascin interactions EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS		Psoriasis ( 20953189)
Protein-Protein Interactions		13 interactors: CASK CCL5 CXCR4 GIPC1 MDK PRKCA PRKCD PXN SDCBP SGTA TANK TGFB1I1 TGFB3	167 interactors: ABI2 AES ANKRD40 ANP32B APIP BCL2L15 C11orf57 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CCDC102B CCDC36 CCDC53 CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DAK DCTD DCTPP1 DMC1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRM3 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NOTCH2NL NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTPRJ PTS PUF60 PYCRL RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SDCCAG3 SEPT3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBE2A ULK1 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17
Entrez ID		6385	6386
HPRD ID		08366	03741
Ensembl ID		ENSG00000124145	ENSG00000137575
Uniprot IDs		B4E1S6 P31431	B4DHN5 G5EA09 O00560
PDB IDs		1EJP 1EJQ 1OBY 1YBO	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Neutrophil Activation Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Positive Regulation Of MAPK Cascade Cell Migration Positive Regulation Of Phosphorylation Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Signaling Positive Regulation Of Cellular Biosynthetic Process Cell Communication Positive Regulation Of Phospholipase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Growth Factor Response To Stress Regulation Of Phospholipase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipase Activity Cell Adhesion Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Dendritic Cell Chemotaxis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transport Regulation Of Platelet Aggregation	Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neuron-neuron Synaptic Transmission Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Synaptic Transmission Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Homooligomerization Positive Regulation Of Exocytosis Protein Tetramerization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Metabolic Process Regulation Of Cellular Component Organization Protein Oligomerization Protein Homotetramerization Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Stimulus Cell-cell Signaling Regulation Of Synaptic Transmission Cellular Process Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Viral Release From Host Cell Gene Expression Positive Regulation Of Secretion Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process RNA Splicing Protein Modification By Small Protein Conjugation Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Ephrin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Nucleoside Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Synaptic Transmission RNA Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Protein Polyubiquitination
Tagcloud ?		alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading syndecan syndecans utilized	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound
Tagcloud (Difference) ?		alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading utilized	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syntenin triggered unrelated uveal warrants wound
Tagcloud (Intersection) ?		syndecan syndecans