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SDC4
Gene Name
syndecan 4
Image
Gene Ontology Annotations
Cellular Component
Golgi Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Costamere
Lysosomal Lumen
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Fibronectin Binding
Protein Kinase C Binding
Protein Binding
Thrombospondin Receptor Activity
Biological Process
Retinoid Metabolic Process
Ureteric Bud Development
Carbohydrate Metabolic Process
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Phototransduction, Visible Light
Biological_process
Pathogenesis
Extracellular Matrix Organization
Glycosaminoglycan Metabolic Process
Chondroitin Sulfate Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Defective B4GALT7 causes EDS, progeroid type
Heparan sulfate/heparin (HS-GAG) metabolism
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Chondroitin sulfate/dermatan sulfate metabolism
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Defective CHST14 causes EDS, musculocontractural type
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
Defective CHST6 causes MCDC1
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
A tetrasaccharide linker sequence is required for GAG synthesis
MPS IIIC - Sanfilippo syndrome C
Retinoid metabolism and transport
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Non-integrin membrane-ECM interactions
Diseases associated with visual transduction
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Syndecan interactions
MPS IV - Morquio syndrome A
Visual phototransduction
MPS IV - Morquio syndrome B
Defective CHSY1 causes TPBS
MPS VII - Sly syndrome
Metabolism of carbohydrates
HS-GAG biosynthesis
HS-GAG degradation
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Psoriasis (
20953189
)
Protein-protein Interactions
13 interactors:
CASK
CCL5
CXCR4
GIPC1
MDK
PRKCA
PRKCD
PXN
SDCBP
SGTA
TANK
TGFB1I1
TGFB3
Entrez ID
6385
HPRD ID
08366
Ensembl ID
ENSG00000124145
Uniprot IDs
B4E1S6
P31431
PDB IDs
1EJP
1EJQ
1OBY
1YBO
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Neutrophil Activation
Regulation Of MAP Kinase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Behavior
Positive Regulation Of MAPK Cascade
Cell Migration
Positive Regulation Of Phosphorylation
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell Motility
Positive Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Regulation Of Signaling
Signaling
Positive Regulation Of Cellular Biosynthetic Process
Cell Communication
Positive Regulation Of Phospholipase Activity
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Phosphorylation
Negative Regulation Of Glial Cell Apoptotic Process
Response To Growth Factor
Response To Stress
Regulation Of Phospholipase Activity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Lipase Activity
Cell Adhesion
Cell Activation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Leukocyte Chemotaxis
Locomotion
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Protein Phosphorylation
Dendritic Cell Chemotaxis
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transport
Regulation Of Platelet Aggregation
Tagcloud
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alpha3beta1
alpha6beta4
beta4
block
c2
competes
coupling
depends
egf
engagement
engaging
extreme
her1
integrin
laminin
ln332
matrix
migration
penetrating
platform
qeexyx
recognize
sdc1
shares
spreading
syndecan
syndecans
utilized