SDC4

Description		syndecan 4
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GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Costamere Lysosomal Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity
	Biological Process	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Malaria ( 31844061) Psoriasis ( 20953189)
Novel Interacting Genes		1 novel interacting genes: EP300
Interacting Genes		19 interacting genes: CASK CCL5 CXCR4 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC
Entrez ID		6385
HPRD ID		08366
Ensembl ID		ENSG00000124145
Uniprot IDs		B4E1S6 P31431
PDB IDs		1EJP 1EJQ 1OBY 1YBO 8BLV
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition TRC Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Protein Kinase C Signaling Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transport Signal Transduction Regulation Of Smooth Muscle Cell Proliferation Intracellular Signaling Cassette Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Response To Stress Locomotion Cell Migration Regulation Of Response To Wounding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Leukocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Developmental Process Schmidt-Lanterman Incisure Regulation Of Proteolysis Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Wound Healing Regulation Of Cell Projection Organization
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