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SDC4 and PXN
Number of citations of the paper that reports this interaction (PubMedID
11805099
)
0
Data Source:
HPRD
(in vitro)
SDC4
PXN
Description
syndecan 4
paxillin
Image
GO Annotations
Cellular Component
Extracellular Region
Golgi Lumen
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Costamere
Lysosomal Lumen
Extracellular Exosome
Stress Fiber
Cytoplasm
Cytosol
Cytoskeleton
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Anchoring Junction
Molecular Function
Fibronectin Binding
Protein Kinase C Binding
Protein Binding
Identical Protein Binding
Thrombospondin Receptor Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Biological Process
Ureteric Bud Development
Neural Tube Closure
Regulation Of Fibroblast Migration
Cell Migration
Wound Healing
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Inner Ear Receptor Cell Stereocilium Organization
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Cell Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Migration
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
Pathways
Glycosaminoglycan-protein linkage region biosynthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Attachment and Entry
Attachment and Entry
Retinoid metabolism and transport
Respiratory syncytial virus (RSV) attachment and entry
RSV-host interactions
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS
Malaria (
31844061
)
Psoriasis (
20953189
)
Bipolar disorder (
31043756
)
Left ventricle wall thickness (
33495596
)
Left ventricular end-systolic volume (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
19 interacting genes:
CASK
CCL5
CXCR4
GIPC1
IL7R
MAL
MDK
PMP22
PRKCA
PRKCD
PTEN
PXN
SDCBP
SGTA
SGTB
TANK
TGFB1I1
TGFB3
UBC
86 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LINC00632
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
Entrez ID
6385
5829
HPRD ID
08366
03937
Ensembl ID
ENSG00000124145
ENSG00000089159
Uniprot IDs
B4E1S6
P31431
A0A140VJQ8
A0A1B0GTU4
F5GZ78
P49023
PDB IDs
1EJP
1EJQ
1OBY
1YBO
8BLV
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
7QB0
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Metabolic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
TRC Complex
Positive Regulation Of Cell Differentiation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Population Proliferation
Positive Regulation Of Biosynthetic Process
Protein Kinase C Signaling
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Receptor Signaling Pathway Via STAT
Regulation Of Multicellular Organismal Process
Regulation Of Cell Differentiation
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Transport
Signal Transduction
Regulation Of Smooth Muscle Cell Proliferation
Intracellular Signaling Cassette
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Macromolecule Metabolic Process
Apoptotic Process
Response To Stress
Locomotion
Cell Migration
Regulation Of Response To Wounding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Population Proliferation
Programmed Cell Death
Cell Death
Negative Regulation Of Glial Cell Apoptotic Process
Positive Regulation Of Leukocyte Differentiation
Regulation Of Cell Activation
Positive Regulation Of Developmental Process
Schmidt-Lanterman Incisure
Regulation Of Proteolysis
Protein Targeting To Membrane
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Wound Healing
Regulation Of Cell Projection Organization
Focal Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cell Adhesion
Integrin-mediated Signaling Pathway
Cell Migration
Regulation Of Cellular Component Organization
Cell Surface Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Anchoring Junction
Cell Motility
Regulation Of Cytoskeleton Organization
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Cell Migration
Regulation Of Intracellular Signal Transduction
Cytosol
Regulation Of Cell Motility
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Migration
Regulation Of Locomotion
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Cell-substrate Adhesion
Protein Kinase Activity
Regulation Of Cell-matrix Adhesion
Cell Projection Organization
Regulation Of Immune System Process
Lamellipodium
Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cytoplasm
Regulation Of MAPK Cascade
Plasma Membrane
Regulation Of Cellular Localization
Regulation Of Protein Localization
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Organelle Organization
Kinase Activity
Positive Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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