SDC4 and PRKCA

Number of citations of the paper that reports this interaction (PMID 11916978)
16

Data Source:
HPRD (in vitro)

		SDC4	PRKCA
Gene Name		syndecan 4	protein kinase C, alpha
Image
Gene Ontology Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Thrombospondin Receptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)
	Biological Process	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly	Inactivation Of MAPK Activity Mitotic Cell Cycle Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of The Force Of Heart Contraction Chondrocyte Differentiation Desmosome Assembly Energy Reserve Metabolic Process Protein Phosphorylation Cellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Mitotic Nuclear Envelope Disassembly Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Induction Of Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Carbohydrate Stimulus Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Mitotic Prophase Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements Opioid Signalling Diseases associated with visual transduction EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Syndecan interactions GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors Nuclear Envelope Breakdown HuR stabilizes mRNA DAG and IP3 signaling M Phase VEGFA-VEGFR2 Pathway CaM pathway Inactivation, recovery and regulation of the phototransduction cascade EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR The phototransduction cascade Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Depolymerisation of the Nuclear Lamina Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Non-integrin membrane-ECM interactions Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors Cell Cycle, Mitotic Signaling by FGFR beta-catenin independent WNT signaling Acetylcholine regulates insulin secretion Visual phototransduction Ca2+ pathway PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs			Phosphatidylserine Vitamin E Ingenol Mebutate Ellagic Acid
Diseases
GWAS		Psoriasis ( 20953189)	Height ( 22021425) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Ventricular conduction ( 21076409)
Protein-Protein Interactions		13 interactors: CASK CCL5 CXCR4 GIPC1 MDK PRKCA PRKCD PXN SDCBP SGTA TANK TGFB1I1 TGFB3	210 interactors: ACTA1 ADAP1 ADCY5 ADD3 ADRA1B ADRBK1 AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CASR CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GNB2L1 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRM1 GRM5 GSK3A GSK3B HABP4 HAND1 HAND2 HES1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T HIST1H3A HIST3H3 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NFATC1 NFE2L2 NFKBIA NOS1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PICK1 PLCB1 PLD1 PLD2 POLB PPARA PPARG PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SDPR SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		6385	5578
HPRD ID		08366	01498
Ensembl ID		ENSG00000124145	ENSG00000154229
Uniprot IDs		B4E1S6 P31431	P17252 Q7Z727
PDB IDs		1EJP 1EJQ 1OBY 1YBO	2ELI 3IW4 4DNL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Neutrophil Activation Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Positive Regulation Of MAPK Cascade Cell Migration Positive Regulation Of Phosphorylation Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Signaling Positive Regulation Of Cellular Biosynthetic Process Cell Communication Positive Regulation Of Phospholipase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Growth Factor Response To Stress Regulation Of Phospholipase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipase Activity Cell Adhesion Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Dendritic Cell Chemotaxis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transport Regulation Of Platelet Aggregation	Response To Stimulus Cellular Response To Stimulus Regulation Of Signaling Signaling Cell Communication Developmental Process Response To Organic Substance Positive Regulation Of Metabolic Process Response To Stress Multicellular Organismal Development Response To Wounding Cell Differentiation Anatomical Structure Development Regulation Of Cellular Process Signal Transduction Wound Healing Regulation Of Signal Transduction Hemostasis Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Blood Coagulation Regulation Of Body Fluid Levels System Development Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Locomotion Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Development Regulation Of Catalytic Activity Positive Regulation Of Transport Regulation Of Metabolic Process Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Neurogenesis Nervous System Development Organ Development Generation Of Neurons Cell-cell Signaling Intracellular Signal Transduction Regulation Of Cell Differentiation Response To Organic Cyclic Compound Platelet Activation Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading syndecan syndecans utilized	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Difference) ?		alpha3beta1 alpha6beta4 beta4 c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc1 shares spreading syndecan syndecans utilized	american artiodactyla assigned blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Intersection) ?		block