SCN5A and SNTA1

Number of citations of the paper that reports this interaction (PMID 9412493)
66

Data Source:
HPRD (in vivo)

		SCN5A	SNTA1
Gene Name		sodium channel, voltage gated, type V alpha subunit	syntrophin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane T-tubule Sarcolemma	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Scaffold Protein Binding	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Axon Guidance Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Mexiletine Hexylcaine Dibucaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine
Diseases
GWAS		Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) PR interval ( 20062060 23139255 21347284) QT interval ( 19305408 19305409) Ventricular conduction ( 21076409)
Protein-Protein Interactions		17 interactors: CALM1 CBL CDK2 DLG1 DLG2 DLG3 DLG4 INADL NEDD4 NEDD4L RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		6331	6640
HPRD ID		02543	03009
Ensembl ID		ENSG00000183873	ENSG00000101400
Uniprot IDs		E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	B4DX40 Q13424
PDB IDs		2KBI 2L53 4DCK 4DJC
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Receptor Clustering Nucleotide Phosphorylation Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle System Process Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Muscle Contraction Negative Regulation Of Sodium Ion Transport Synaptic Transmission Regulation Of Protein Metabolic Process Negative Regulation Of Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Catalytic Activity Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Signaling Protein Localization To Membrane Regulation Of Dephosphorylation Positive Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Signal Transduction Cortical Cytoskeleton Organization Membrane Organization Protein Polyubiquitination Synapse Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein K63-linked Ubiquitination	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?