SCN5A and EMC9

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SCN5A	EMC9
Name		sodium voltage-gated channel alpha subunit 5	ER membrane protein complex subunit 9
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Membrane Lateral Plasma Membrane Z Disc T-tubule Monoatomic Ion Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm Anchoring Junction	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding	Protein Binding Membrane Insertase Activity
	Biological Process	Regulation Of Heart Rate Cardiac Conduction System Development Cardiac Ventricle Development Brainstem Development Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Telencephalon Development Cerebellum Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	None
Drugs		Indecainide Ranolazine Phenytoin Topiramate Disopyramide Lidocaine Valproic acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Lamotrigine Carbamazepine Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Promethazine Chloroprocaine Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Dronedarone Brivaracetam Vernakalant Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Isavuconazole Dichlorobenzyl alcohol Bioallethrin Fish oil	None
Diseases		Atrial fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Familial idiopathic ventricular fibrillation Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	None
GWAS		Atrial fibrillation ( 29892015 30061737 ) Brugada syndrome ( 35210625 32619740 23872634 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 19389651 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) P wave duration ( 24850809 28794112 ) PR interval ( 21347284 32439900 29127183 30046033 20062060 25035420 23139255 31217584 ) PR segment duration ( 24850809 ) QRS duration ( 31217584 31251759 27577874 25035420 21076409 ) QT interval ( 29213071 29874175 19305408 24952745 19305409 ) Resting heart rate ( 27798624 ) Supraventricular ectopy ( 29618737 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) TPE interval (resting) ( 32386560 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: ANKS1A BANP CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 EMC9 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 TEKT4 WWP2 ZMYND19	2 interacting genes: EMC2 SCN5A
Entrez ID		6331	51016
HPRD ID		02543	16596
Ensembl ID		ENSG00000183873	ENSG00000100908
Uniprot IDs		E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	H0YNH6 Q9Y3B6
PDB IDs		2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6LQA 6MUD 7DTC 7L83 8VYJ 8VYK	6Y4L 6Z3W
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Binding Regulation Of Potassium Ion Export Across Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Dystrophin-associated Glycoprotein Complex Transmembrane Transporter Binding Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Neuromuscular Junction Potassium Channel Inhibitor Activity Negative Regulation Of Transmembrane Transport Receptor Localization To Synapse Receptor Clustering Negative Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Localization To Synapse Regulation Of Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Plasma Membrane Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Structural Molecule Activity PDZ Domain Binding Protein Localization To Cell Junction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Kinase Binding Syntrophin Complex Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Sarcolemma Regulation Of Transport Neuroligin Family Protein Binding Regulation Of Sodium Ion Transmembrane Transport Muscle System Process Protein Kinase Binding Sodium Channel Inhibitor Activity Protein Monoubiquitination GMP Kinase Activity Neuron Projection Synaptic Membrane GDP Metabolic Process Adherens Junction	Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Extrinsic Component Of Endoplasmic Reticulum Membrane Bundle Of His Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Brainstem Development Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation AV Node Cell To Bundle Of His Cell Communication Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Cardiac Ventricle Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential AV Node Cell Action Potential Positive Regulation Of Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization EMC Complex Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Response To Inactivity Voltage-gated Sodium Channel Complex Nitric-oxide Synthase Binding Membrane Depolarization During Cardiac Muscle Cell Action Potential Cardiac Conduction System Development Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Ankyrin Binding Fibroblast Growth Factor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cell Communication Involved In Cardiac Conduction Membrane Depolarization During Action Potential Telencephalon Development Regulation Of Cardiac Muscle Cell Contraction Protein Insertion Into ER Membrane Positive Regulation Of Sodium Ion Transport Sodium Channel Activity Monoatomic Cation Channel Activity Regulation Of Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate By Cardiac Conduction