SCN5A and CALM1

Number of citations of the paper that reports this interaction (PMID 15746172)
27

Data Source:
BioGRID (two hybrid)

		SCN5A	CALM1
Gene Name		sodium channel, voltage gated, type V alpha subunit	calmodulin 1 (phosphorylase kinase, delta)
Image
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane T-tubule Sarcolemma	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Spindle Microtubule Plasma Membrane Sarcomere Growth Cone Vesicle Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Scaffold Protein Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Thioesterase Binding N-terminal Myristoylation Domain Binding Phospholipase Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Ion Channel Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity
	Biological Process	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Axon Guidance Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport	Response To Amphetamine Regulation Of Heart Rate Platelet Degranulation Detection Of Calcium Ion Carbohydrate Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Muscle Contraction Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Rhodopsin Mediated Signaling Pathway Substantia Nigra Development Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Fc-epsilon Receptor Signaling Pathway Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Ca-dependent events CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by Wnt Platelet degranulation Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling Glucose metabolism DAP12 signaling Synthesis of IP3 and IP4 in the cytosol Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions Glycogen breakdown (glycogenolysis) Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Inositol phosphate metabolism EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Signaling by ERBB2 Signaling by EGFR Signaling by VEGF CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events CREB phosphorylation through the activation of CaMKII Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Metabolism of carbohydrates Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Organelle biogenesis and maintenance Cam-PDE 1 activation Translocation of GLUT4 to the plasma membrane VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Inactivation, recovery and regulation of the phototransduction cascade Metabolism of nitric oxide VEGFR2 mediated cell proliferation VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events The phototransduction cascade Downstream signaling of activated FGFR DARPP-32 events eNOS activation and regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Post NMDA receptor activation events Signalling by NGF PLC beta mediated events Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis beta-catenin independent WNT signaling Signaling by FGFR eNOS activation Cam-PDE 1 activation Ca2+ pathway Visual phototransduction Activation of CaMK IV PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs		Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Mexiletine Hexylcaine Dibucaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine
Diseases
GWAS		Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) PR interval ( 20062060 23139255 21347284) QT interval ( 19305408 19305409) Ventricular conduction ( 21076409)
Protein-Protein Interactions		17 interactors: CALM1 CBL CDK2 DLG1 DLG2 DLG3 DLG4 INADL NEDD4 NEDD4L RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2	232 interactors: ACADM ADCY8 ADCYAP1R1 ADD1 ADD2 AKAP5 AKAP6 AKAP9 AR ARHGEF7 ARMC1 ASCL2 ATP2B1 ATRX BRWD1 C11orf65 CABIN1 CALCR CALD1 CAMK1 CAMK2G CAMKK1 CAMKK2 CASP8AP2 CCDC14 CCNA2 CCND1 CCND2 CCNE1 CCP110 CDC37L1 CDC5L CKMT1B CLINT1 CLIP1 CLTB CNGA2 CNN1 CRHR1 CSNK2A1 CSNK2A2 CSNK2B DAPK1 DCTN2 DCUN1D1 DDAH1 DDX21 DDX5 DLG3 DMXL1 DNAJC13 DOCK11 DOCK3 DRD2 DST EDF1 EGFR EIF3C ESR1 ESR2 ESRRG EWSR1 FAM178A FAS FBXO9 FER FKBP3 FKBP4 GAP43 GCLM GJB1 GLP1R GLP2R GNAS GRB7 GRIN1 GRK1 GRK4 GRK5 GRM3 GRM4 GRM5 GRM7 GTF2I H2AFX HERC2 HMMR HSP90AA1 HSPA4 HTR2C HUWE1 IMMT INSR IQGAP1 IQGAP2 ITGA6 ITPKA ITPKB KCNH1 KCNN2 KCNN3 KCNN4 KCNQ2 KCNQ3 KCNQ5 KDM5C KIAA0020 KIAA1683 KIF1B KRAS LACTB LMO7 LTF LUC7L LY96 LYST MAPT MATR3 MBIP METAP2 MIP MORF4L1 MYBPC1 MYCBP2 MYF5 MYF6 MYLK MYO10 MYO7A MYO9B MYOD1 MYOG NBR1 NEB NEUROD1 NEXN NOL7 NOS3 NR3C1 NRGN NT5C2 OBSCN OPALIN OPRM1 OPTN PAM PCNT PCP4 PDCD7 PDE1A PHACTR4 PHKG1 PIK3C3 PLCD1 POLR2B PPEF1 PPEF2 PPIL2 PRDX1 PSMD12 PSMD2 PTAFR PTH2R PTPRA RAB3B RAD23B RALA RALB RANBP2 RDX REL RELA RGS10 RGS2 RGS4 RIT2 RPL13A RPL22 RPS14 RPS15A RPS4Y1 RPS8 RRAD RYR1 RYR2 S100B SCAPER SCLT1 SCN4A SCN5A SCTR SEC61A1 SET SF3B1 SLTM SNCA SNRPB2 SNTA1 SNX6 SPP1 SQSTM1 SRP14 SRSF5 STAG1 STIM2 STK38 STRN STRN3 STRN4 STX8 SYK SYNE2 SYT1 TCF3 TCF4 THOP1 TNNI2 TPT1 TRDN TRPC3 TRPV1 TRPV4 TRPV6 TSC2 TTN UCHL5 USP16 VIPR1 XRCC4 YBX1 YWHAE ZBTB24
Entrez ID		6331	801
HPRD ID		02543	00241
Ensembl ID		ENSG00000183873	ENSG00000198668
Uniprot IDs		E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	B4DJ51 E7ETZ0 P62158
PDB IDs		2KBI 2L53 4DCK 4DJC	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M55 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4DCK 4DJC 4GOW
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Receptor Clustering Nucleotide Phosphorylation Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle System Process Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Muscle Contraction Negative Regulation Of Sodium Ion Transport Synaptic Transmission Regulation Of Protein Metabolic Process Negative Regulation Of Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Catalytic Activity Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Signaling Protein Localization To Membrane Regulation Of Dephosphorylation Positive Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Signal Transduction Cortical Cytoskeleton Organization Membrane Organization Protein Polyubiquitination Synapse Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein K63-linked Ubiquitination	Response To Stimulus Regulation Of Cellular Process Cell Communication Signaling Cellular Response To Stimulus Regulation Of Signaling Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Response To External Stimulus Regulation Of Signal Transduction Developmental Process Regulation Of Catalytic Activity Cellular Process Response To Stress Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound System Development Regulation Of Ion Transport Multicellular Organismal Development Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Localization Synaptic Transmission Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Regulation Of Phosphorylation Locomotion Regulation Of Cellular Localization Positive Regulation Of Cellular Biosynthetic Process Muscle System Process Intracellular Transport Regulation Of Ion Transmembrane Transport Cytoplasmic Transport Movement Of Cell Or Subcellular Component Chemotaxis Regulation Of Cellular Component Organization Nervous System Development Regulation Of Protein Kinase Activity Generation Of Neurons
Tagcloud ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge	considering dysregulated endocrine ep300 facilitates geo give hope hub omnibus partial pls posttraumatic prkca psychological ptsd recovered representations shed signatures square squares supports theoretical top trauma traumatic underlie variance
Tagcloud (Difference) ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge	considering dysregulated endocrine ep300 facilitates geo give hope hub omnibus partial pls posttraumatic prkca psychological ptsd recovered representations shed signatures square squares supports theoretical top trauma traumatic underlie variance
Tagcloud (Intersection) ?