SCN5A and SNTG2

Number of citations of the paper that reports this interaction (PMID 12429735)
24

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SCN5A	SNTG2
Gene Name		sodium channel, voltage gated, type V alpha subunit	syntrophin, gamma 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane T-tubule Sarcolemma	Cytoplasm Cytoskeleton Syntrophin Complex Sarcolemma
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Scaffold Protein Binding	Actin Binding PDZ Domain Binding
	Biological Process	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Axon Guidance Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport	Central Nervous System Development
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Mexiletine Hexylcaine Dibucaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine
Diseases
GWAS		Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) PR interval ( 20062060 23139255 21347284) QT interval ( 19305408 19305409) Ventricular conduction ( 21076409)
Protein-Protein Interactions		17 interactors: CALM1 CBL CDK2 DLG1 DLG2 DLG3 DLG4 INADL NEDD4 NEDD4L RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2	6 interactors: BAI1 DMD DTNA DTNB MPP3 SCN5A
Entrez ID		6331	54221
HPRD ID		02543	16374
Ensembl ID		ENSG00000183873	ENSG00000172554
Uniprot IDs		E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	Q9NY99
PDB IDs		2KBI 2L53 4DCK 4DJC
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Receptor Clustering Nucleotide Phosphorylation Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle System Process Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Muscle Contraction Negative Regulation Of Sodium Ion Transport Synaptic Transmission Regulation Of Protein Metabolic Process Negative Regulation Of Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Catalytic Activity Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Signaling Protein Localization To Membrane Regulation Of Dephosphorylation Positive Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Signal Transduction Cortical Cytoskeleton Organization Membrane Organization Protein Polyubiquitination Synapse Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein K63-linked Ubiquitination	Striated Muscle Contraction Muscle Contraction Muscle System Process Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Cardiac Muscle Contraction Regulation Of Sodium Ion Transport Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Action Potential Regulation Of Striated Muscle Contraction Peripheral Nervous System Development Establishment Of Glial Blood-brain Barrier Regulation Of Muscle Contraction Cell Projection Morphogenesis Regulation Of Ion Homeostasis Cell Part Morphogenesis Regulation Of Heart Contraction Cell-cell Signaling Negative Regulation Of Peptidyl-cysteine S-nitrosylation Membrane Depolarization During SA Node Cell Action Potential Positive Regulation Of Ion Transport Signaling Cell Morphogenesis Cell Communication SA Node Cell Action Potential Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier AV Node Cell To Bundle Of His Cell Communication Cell Projection Organization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Olfactory Nerve Development Regulation Of Skeletal Muscle Contraction SA Node Cell To Atrial Cardiac Muscle Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication Blood Circulation Neurotransmitter Receptor Metabolic Process Cellular Response To Stimulus Positive Regulation Of Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Response To Denervation Involved In Regulation Of Muscle Adaptation Motile Cilium Assembly Membrane Depolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Response To Inactivity Generation Of Neurons
Tagcloud ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Difference) ?		abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Intersection) ?