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SCN5A and SNTB1
Number of citations of the paper that reports this interaction (PMID
9412493
)
66
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
SCN5A
SNTB1
Gene Name
sodium channel, voltage gated, type V alpha subunit
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Voltage-gated Sodium Channel Complex
Endoplasmic Reticulum
Plasma Membrane
Caveola
Cell Surface
Intercalated Disc
Integral Component Of Membrane
Lateral Plasma Membrane
T-tubule
Sarcolemma
Cytoplasm
Cytoskeleton
Focal Adhesion
Dystrophin-associated Glycoprotein Complex
Sarcolemma
Protein Complex
Synapse
Molecular Function
Voltage-gated Sodium Channel Activity
Protein Binding
Calmodulin Binding
Fibroblast Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Ankyrin Binding
Ubiquitin Protein Ligase Binding
Ion Channel Binding
Nitric-oxide Synthase Binding
Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
Scaffold Protein Binding
Actin Binding
Protein Binding
Calmodulin Binding
PDZ Domain Binding
Biological Process
Regulation Of Heart Rate
Cardiac Ventricle Development
Brainstem Development
Sodium Ion Transport
Axon Guidance
Positive Regulation Of Sodium Ion Transport
Response To Denervation Involved In Regulation Of Muscle Adaptation
Neuronal Action Potential
Telencephalon Development
Cerebellum Development
Sodium Ion Transmembrane Transport
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Action Potential
Positive Regulation Of Epithelial Cell Proliferation
Membrane Depolarization
Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Cellular Response To Calcium Ion
Cardiac Muscle Cell Action Potential Involved In Contraction
Regulation Of Cardiac Muscle Cell Contraction
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Depolarization During Cardiac Muscle Cell Action Potential
Membrane Depolarization During SA Node Cell Action Potential
AV Node Cell To Bundle Of His Cell Communication
Bundle Of His Cell To Purkinje Myocyte Communication
SA Node Cell To Atrial Cardiac Muscle Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Sodium Ion Transmembrane Transport
Muscle Contraction
Pathways
Interaction between L1 and Ankyrins
Axon guidance
L1CAM interactions
Drugs
Indecainide
Ranolazine
Phenytoin
Disopyramide
Lidocaine
Mexiletine
Hexylcaine
Dibucaine
Mephenytoin
Carbamazepine
Verapamil
Moricizine
Riluzole
Prilocaine
Ethotoin
Oxcarbazepine
Benzonatate
Cocaine
Quinidine
Zonisamide
Procainamide
Tocainide
Propafenone
Flecainide
Encainide
Fosphenytoin
Quinidine barbiturate
Ajmaline
Aprindine
Diseases
GWAS
Electrocardiographic conduction measures (
23463857
19389651
)
Electrocardiographic traits (
20062063
)
PR interval (
20062060
23139255
21347284
)
QT interval (
19305408
19305409
)
Ventricular conduction (
21076409
)
Myopia (pathological) (
23406873
)
Protein-Protein Interactions
17 interactors:
CALM1
CBL
CDK2
DLG1
DLG2
DLG3
DLG4
INADL
NEDD4
NEDD4L
RGS2
RGS3
SNTA1
SNTB1
SNTB2
SNTG2
WWP2
11 interactors:
ABCA1
ADRA1D
BAI1
DGKZ
DMD
DTNA
KCNJ12
MAPK12
SCN4A
SCN5A
UTRN
Entrez ID
6331
6641
HPRD ID
02543
02490
Ensembl ID
ENSG00000183873
ENSG00000172164
Uniprot IDs
E9PG18
E9PHB6
H9KVD2
K4DIA1
Q14524
Q86V90
Q13884
PDB IDs
2KBI
2L53
4DCK
4DJC
Enriched GO Terms of Interacting Partners
?
Receptor Localization To Synapse
Protein Localization To Synapse
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Receptor Clustering
Nucleotide Phosphorylation
Regulation Of Potassium Ion Transport
Regulation Of Ion Transport
Regulation Of Sodium Ion Transport
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cardiac Muscle Contraction
Regulation Of Striated Muscle Contraction
Muscle System Process
Regulation Of Potassium Ion Transmembrane Transporter Activity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Transporter Activity
Regulation Of Muscle Contraction
Regulation Of Heart Contraction
Negative Regulation Of Transport
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Muscle Contraction
Negative Regulation Of Sodium Ion Transport
Synaptic Transmission
Regulation Of Protein Metabolic Process
Negative Regulation Of Ion Transport
Regulation Of Phosphatase Activity
Negative Regulation Of Signal Transduction
Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Ventricular Cardiac Muscle Cell Action Potential
Negative Regulation Of Signaling
Protein Localization To Membrane
Regulation Of Dephosphorylation
Positive Regulation Of Transport
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of Membrane Repolarization
Cortical Actin Cytoskeleton Organization
Cardiac Muscle Cell Action Potential Involved In Contraction
Regulation Of Signal Transduction
Cortical Cytoskeleton Organization
Membrane Organization
Protein Polyubiquitination
Synapse Organization
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Protein K63-linked Ubiquitination
Muscle Contraction
Muscle System Process
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Regulation Of Heart Contraction
Regulation Of Sodium Ion Transport
Regulation Of Ion Transport
Signaling
Cell Communication
Action Potential
Striated Muscle Contraction
Cell-cell Signaling
Regulation Of Sodium Ion Transmembrane Transporter Activity
Neuronal Action Potential
Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Positive Regulation Of Sodium Ion Transport
Regulation Of Membrane Potential
Muscle Organ Development
Cardiac Muscle Contraction
Positive Regulation Of Cell-matrix Adhesion
Transmission Of Nerve Impulse
Blood Circulation
Heart Contraction
Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure
Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction
Regulation Of Cellular Process
Regulation Of Striated Muscle Contraction
Establishment Of Glial Blood-brain Barrier
Peripheral Nervous System Development
Membrane Depolarization
Regulation Of Cell-matrix Adhesion
Positive Regulation Of Cell-substrate Adhesion
G-protein Coupled Receptor Signaling Pathway
Muscle Structure Development
Negative Regulation Of Peptidyl-cysteine S-nitrosylation
Membrane Depolarization During SA Node Cell Action Potential
Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
Interleukin-1 Beta Secretion
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Synaptic Transmission
Ion Transmembrane Transport
Regulation Of Muscle Contraction
SA Node Cell Action Potential
Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion
Establishment Of Blood-nerve Barrier
AV Node Cell To Bundle Of His Cell Communication
Cellular Response To Stimulus
Tagcloud
?
abbreviated
abbreviating
apd90
arrhythmogenesis
arterially
atx
bifurcated
dispersion
endocardial
epicardial
extrastimuli
herg
lqt2
lqt3
lqts
mexiletine
pacing
pointes
prolongation
purkinje
qt
repolarization
sotalol
steeper
tdr
torsade
totally
transmural
wedge
Tagcloud (Difference)
?
abbreviated
abbreviating
apd90
arrhythmogenesis
arterially
atx
bifurcated
dispersion
endocardial
epicardial
extrastimuli
herg
lqt2
lqt3
lqts
mexiletine
pacing
pointes
prolongation
purkinje
qt
repolarization
sotalol
steeper
tdr
torsade
totally
transmural
wedge
Tagcloud (Intersection)
?