SCN5A and SNTB1

Number of citations: 64 (PubMedID 9412493)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		SCN5A	SNTB1
Name		sodium voltage-gated channel alpha subunit 5	syntrophin beta 1
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Membrane Lateral Plasma Membrane Z Disc T-tubule Monoatomic Ion Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm Anchoring Junction	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Protein-containing Complex Sarcolemma Synapse Anchoring Junction
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Regulation Of Heart Rate Cardiac Conduction System Development Cardiac Ventricle Development Brainstem Development Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Telencephalon Development Cerebellum Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Muscle Contraction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Indecainide Ranolazine Phenytoin Topiramate Disopyramide Lidocaine Valproic acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Lamotrigine Carbamazepine Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Promethazine Chloroprocaine Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Dronedarone Brivaracetam Vernakalant Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Isavuconazole Dichlorobenzyl alcohol Bioallethrin Fish oil	None
Diseases		Atrial fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Familial idiopathic ventricular fibrillation Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	None
GWAS		Atrial fibrillation ( 29892015 30061737 ) Brugada syndrome ( 35210625 32619740 23872634 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 19389651 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) P wave duration ( 24850809 28794112 ) PR interval ( 21347284 32439900 29127183 30046033 20062060 25035420 23139255 31217584 ) PR segment duration ( 24850809 ) QRS duration ( 31217584 31251759 27577874 25035420 21076409 ) QT interval ( 29213071 29874175 19305408 24952745 19305409 ) Resting heart rate ( 27798624 ) Supraventricular ectopy ( 29618737 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) TPE interval (resting) ( 32386560 )	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809 ) Cerebrospinal T-tau levels ( 28247064 ) Eye morphology ( 29921221 ) HDL cholesterol levels ( 32203549 28334899 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 29083408 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Myopia (pathological) ( 23406873 ) Myopia (severe) ( 23933737 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thalamus volume ( 31530798 )
Interacting Genes		23 interacting genes: ANKS1A BANP CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 EMC9 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 TEKT4 WWP2 ZMYND19	15 interacting genes: ABCA1 ACVR2B ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN VANGL2
Entrez ID		6331	6641
HPRD ID		02543	02490
Ensembl ID		ENSG00000183873	ENSG00000172164
Uniprot IDs		E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90	Q13884
PDB IDs		2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6LQA 6MUD 7DTC 7L83 8VYJ 8VYK	7P70 7PC4
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Binding Regulation Of Potassium Ion Export Across Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Dystrophin-associated Glycoprotein Complex Transmembrane Transporter Binding Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Neuromuscular Junction Potassium Channel Inhibitor Activity Negative Regulation Of Transmembrane Transport Receptor Localization To Synapse Receptor Clustering Negative Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Localization To Synapse Regulation Of Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Plasma Membrane Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Structural Molecule Activity PDZ Domain Binding Protein Localization To Cell Junction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Kinase Binding Syntrophin Complex Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Sarcolemma Regulation Of Transport Neuroligin Family Protein Binding Regulation Of Sodium Ion Transmembrane Transport Muscle System Process Protein Kinase Binding Sodium Channel Inhibitor Activity Protein Monoubiquitination GMP Kinase Activity Neuron Projection Synaptic Membrane GDP Metabolic Process Adherens Junction	Muscle Contraction Muscle System Process Plasma Membrane Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cell Communication Regulation Of Multicellular Organismal Process Lateral Plasma Membrane Regulation Of Sodium Ion Transport Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Blood Circulation Regulation Of System Process Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Signal Transduction Cell-cell Signaling System Process Regulation Of Monoatomic Ion Transmembrane Transport Action Potential Regulation Of Skeletal Muscle Contraction Filopodium Membrane Voltage-gated Sodium Channel Activity Kinase Activity Signaling Establishment Of Planar Polarity Monoatomic Ion Channel Complex Synaptic Signaling Membrane Protein Serine/threonine/tyrosine Kinase Activity Phagocytosis, Engulfment Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Monoatomic Cation Channel Activity Regulation Of Muscle Contraction Sodium Channel Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Developmental Process Regulation Of Biological Quality Regulation Of Heart Contraction Cardiac Muscle Contraction T-tubule ATP Binding Membrane Invagination Sphingolipid Floppase Activity