SERPINB3 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		SERPINB3	UCHL5
Description		serpin family B member 3	ubiquitin C-terminal hydrolase L5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Virus Receptor Activity Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Peptidase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Autocrine Signaling Paracrine Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of JUN Kinase Activity Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Neutrophil degranulation	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs		D-Serine Dexfosfoserine
Diseases
GWAS			Cannabis dependence ( 21668797)
Interacting Genes		7 interacting genes: CDC42 CTSK CTSL CTSS MAPK8 SLC26A4-AS1 UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		6317	51377
HPRD ID		02745	10293
Ensembl ID		ENSG00000057149	ENSG00000116750
Uniprot IDs		P29508	Q5LJA5 Q9Y5K5
PDB IDs		2ZV6 4ZK0 4ZK3	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Endolysosome Lumen Proteoglycan Binding Cysteine-type Peptidase Activity Fibronectin Binding Collagen Catabolic Process Collagen Metabolic Process Cysteine-type Endopeptidase Activity Collagen Binding Lysosomal Lumen Cellular Response To Thyroid Hormone Stimulus Peptidase Activity Response To Thyroid Hormone Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Hydrolase Activity Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane JUN Phosphorylation Phagocytic Vesicle Proteolysis Lysosome Antigen Processing And Presentation GBD Domain Binding Storage Vacuole Enkephalin Processing Endothelin Receptor Signaling Pathway Involved In Heart Process Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Basement Membrane Disassembly JUN Kinase Activity Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Serine-type Endopeptidase Activity Chromaffin Granule Elastin Metabolic Process Histone Deacetylase Regulator Activity Basal Dendrite Protein Metabolic Process Protein Processing Hormone Metabolic Process Inflammatory Cell Apoptotic Process Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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