SERPINB3 and CTSK

Number of citations of the paper that reports this interaction (PubMedID 9548757)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SERPINB3	CTSK
Description		serpin family B member 3	cathepsin K
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endolysosome Lumen Lysosomal Lumen
	Molecular Function	Virus Receptor Activity Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Peptidase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Autocrine Signaling Paracrine Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of JUN Kinase Activity Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell	Mitophagy Proteolysis Thyroid Hormone Generation Extracellular Matrix Disassembly Collagen Catabolic Process Bone Resorption Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cartilage Development
Pathways		Neutrophil degranulation	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs		D-Serine Dexfosfoserine	[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE Balicatib MIV-711
Diseases			Pycnodysostosis
GWAS			Aspartate aminotransferase levels ( 33547301) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		7 interacting genes: CDC42 CTSK CTSL CTSS MAPK8 SLC26A4-AS1 UCHL5	6 interacting genes: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		6317	1513
HPRD ID		02745	03064
Ensembl ID		ENSG00000057149	ENSG00000143387
Uniprot IDs		P29508	P43235
PDB IDs		2ZV6 4ZK0 4ZK3	1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 4N79 4N8W 4X6H 4X6I 4X6J 4YV8 4YVA 5J94 5JA7 5JH3 5TDI 5TUN 5Z5O 6ASH 6HGY 6PXF 6QBS 6QL8 6QLM 6QLW 6QLX 6QM0 7NXL 7NXM 7PCK 7QBL 7QBM 7QBN 7QBO 8C3D
Enriched GO Terms of Interacting Partners?		Endolysosome Lumen Proteoglycan Binding Cysteine-type Peptidase Activity Fibronectin Binding Collagen Catabolic Process Collagen Metabolic Process Cysteine-type Endopeptidase Activity Collagen Binding Lysosomal Lumen Cellular Response To Thyroid Hormone Stimulus Peptidase Activity Response To Thyroid Hormone Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Hydrolase Activity Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane JUN Phosphorylation Phagocytic Vesicle Proteolysis Lysosome Antigen Processing And Presentation GBD Domain Binding Storage Vacuole Enkephalin Processing Endothelin Receptor Signaling Pathway Involved In Heart Process Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Basement Membrane Disassembly JUN Kinase Activity Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Serine-type Endopeptidase Activity Chromaffin Granule Elastin Metabolic Process Histone Deacetylase Regulator Activity Basal Dendrite Protein Metabolic Process Protein Processing Hormone Metabolic Process Inflammatory Cell Apoptotic Process Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process	Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Proteolysis Establishment Of Integrated Proviral Latency Negative Regulation Of Keratinocyte Apoptotic Process Serine-type Endopeptidase Inhibitor Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Establishment Of Viral Latency Protease Binding Positive Regulation Of Hydrolase Activity Positive Regulation Of Phospholipase Activity Bone Maturation Regulation Of Catalytic Activity Extracellular Space Negative Regulation Of Protein Metabolic Process DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Regulation Of Cell Population Proliferation Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Lipase Activity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Regulation Of Keratinocyte Apoptotic Process Autocrine Signaling Negative Regulation Of JUN Kinase Activity Paracrine Signaling Positive Regulation Of Endopeptidase Activity Semicircular Canal Morphogenesis BBSome Endochondral Bone Growth Positive Regulation Of Cell Population Proliferation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Positive Regulation Of Peptidase Activity Lymphoid Progenitor Cell Differentiation
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