SERPINB3 and CTSK

Number of citations of the paper that reports this interaction (PMID 9548757)
36

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SERPINB3	CTSK
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 3	cathepsin K
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endolysosome Lumen
	Molecular Function	Virus Receptor Activity Serine-type Endopeptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Response To Virus Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis	Intramembranous Ossification Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Bone Resorption Proteolysis Involved In Cellular Protein Catabolic Process
Pathways			Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen degradation Activation of Matrix Metalloproteinases MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		5 interactors: CTSK CTSL CTSS MAPK8 UCHL5	6 interactors: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		6317	1513
HPRD ID		02745	03064
Ensembl ID		ENSG00000057149	ENSG00000143387
Uniprot IDs		P29508	P43235
PDB IDs		2ZV6	1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 7PCK
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Immune Response-regulating Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Protein Catabolic Process Positive Regulation Of Immune Response Response To Thyroid Hormone Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Immune Response Regulation Of Immune System Process Defense Response Response To Stress Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Catabolic Process Cellular Response To Organic Substance Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Protein Metabolic Process Immune System Process Basement Membrane Disassembly Macrophage Apoptotic Process Signal Transduction Response To Organic Substance Protein Metabolic Process Signaling Cell Communication Antigen Processing And Presentation Of Peptide Antigen JUN Phosphorylation Positive Regulation Of Deacetylase Activity Adaptive Immune Response Ossification Antigen Processing And Presentation Myeloid Cell Apoptotic Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Somatic Stem Cell Maintenance Platelet Degranulation Regulation Of Endothelial Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway DNA Ligation Involved In DNA Recombination Regulation Of Proteolysis Negative Regulation Of Epithelial Cell Proliferation Cell Activation Response To Wounding Stem Cell Maintenance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Inner Ear Development Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Catalytic Activity Bone Development Ear Development Lagging Strand Elongation Pro-B Cell Differentiation Alveolar Secondary Septum Development Regulation Of Neuron Apoptotic Process Lung Development Axonogenesis Involved In Innervation Stem Cell Development Respiratory Tube Development Response To Abiotic Stimulus Response To Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neuron Death Immunoglobulin V(D)J Recombination Chondrocyte Proliferation Response To L-ascorbic Acid Establishment Of Viral Latency
Tagcloud ?		autocrine contributes contributions cysteine emt halted il6 makes malignancy mammary mechanistically mesenchymal neu nonlethal oncogenic phenotypes prolonged promoted promotes promoting protease protumorigenic scca1 sufficient tumorigenesis unfolded upr upregulated	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		autocrine contributes contributions cysteine emt halted il6 makes malignancy mammary mechanistically mesenchymal neu nonlethal oncogenic phenotypes prolonged promoted promotes promoting protease protumorigenic scca1 sufficient tumorigenesis unfolded upr upregulated	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?