SERPINB3 and CTSL

Number of citations of the paper that reports this interaction (PMID 9548757)
36

Data Source:
HPRD (in vitro)

		SERPINB3	CTSL
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 3	cathepsin L
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Vesicle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Serine-type Endopeptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding
	Biological Process	Response To Virus Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways			Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CTSK CTSL CTSS MAPK8 UCHL5	27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		6317	1514
HPRD ID		02745	00293
Ensembl ID		ENSG00000057149	ENSG00000135047
Uniprot IDs		P29508	P07711 Q9HBQ7
PDB IDs		2ZV6	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Immune Response-regulating Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Protein Catabolic Process Positive Regulation Of Immune Response Response To Thyroid Hormone Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Immune Response Regulation Of Immune System Process Defense Response Response To Stress Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Catabolic Process Cellular Response To Organic Substance Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Protein Metabolic Process Immune System Process Basement Membrane Disassembly Macrophage Apoptotic Process Signal Transduction Response To Organic Substance Protein Metabolic Process Signaling Cell Communication Antigen Processing And Presentation Of Peptide Antigen JUN Phosphorylation Positive Regulation Of Deacetylase Activity Adaptive Immune Response Ossification Antigen Processing And Presentation Myeloid Cell Apoptotic Process	Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation
Tagcloud ?		autocrine contributes contributions cysteine emt halted il6 makes malignancy mammary mechanistically mesenchymal neu nonlethal oncogenic phenotypes prolonged promoted promotes promoting protease protumorigenic scca1 sufficient tumorigenesis unfolded upr upregulated	a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Difference) ?		autocrine contributes contributions cysteine emt halted il6 makes malignancy mammary mechanistically mesenchymal neu nonlethal oncogenic phenotypes prolonged promoted promotes promoting protease protumorigenic scca1 sufficient tumorigenesis unfolded upr upregulated	a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Intersection) ?