RPL4 and NDRG1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		RPL4	NDRG1
Description		ribosomal protein L4	N-myc downstream regulated 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Nuclear Body Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Cytoplasmic Translation Translation	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Artenimol
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		21 interacting genes: APBB1 APOE DUX4 DUX4L9 FOXP1 IL32 MAP3K14 MDM2 MYB NDRG1 OGT PBX2 PIN1 PRDX2 PRPF40A RBFOX2 SF3B6 SORBS1 SUMO2 TNPO2 TSC2	71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		6124	10397
HPRD ID		01607	05586
Ensembl ID		ENSG00000174444	ENSG00000104419
Uniprot IDs		P36578	Q8N959 Q92597
PDB IDs		4UG0 4V6X 5A8L 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	6ZMM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Lipid Biosynthetic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Signal Transduction Low-density Lipoprotein Particle Receptor Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Phospholipid Efflux Regulation Of Wnt Signaling Pathway Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cell Population Proliferation Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Signaling Negative Regulation Of Developmental Process Antioxidant Activity Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Protein Metabolic Process	Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression
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