RPL4 and TSC2

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		RPL4	TSC2
Name		ribosomal protein L4	TSC complex subunit 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Nuclear Body Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Cytoplasmic Translation Translation	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs		Artenimol	None
Diseases		None	Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		No GWAS studies recorded	Major depressive disorder ( 29317602 ) Obesity-related traits ( 23251661 ) White blood cell count ( 32888494 )
Interacting Genes		21 interacting genes: APBB1 APOE DUX4 DUX4L9 FOXP1 IL32 MAP3K14 MDM2 MYB NDRG1 OGT PBX2 PIN1 PRDX2 PRPF40A RBFOX2 SF3B6 SORBS1 SUMO2 TNPO2 TSC2	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6124	7249
HPRD ID		01607	01850
Ensembl ID		ENSG00000174444	ENSG00000103197
Uniprot IDs		P36578	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs		4UG0 4V6X 5A8L 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO	7DL2 9CE3
GO Terms Enriched among Interactors		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Lipid Biosynthetic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Signal Transduction Low-density Lipoprotein Particle Receptor Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Phospholipid Efflux Regulation Of Wnt Signaling Pathway Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cell Population Proliferation Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Signaling Negative Regulation Of Developmental Process Antioxidant Activity Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Protein Metabolic Process	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity