H2AC4 and PTEN

Number of citations of the paper that reports this interaction (PubMedID 26561776)
0

Data Source:
BioGRID (pull down)

		H2AC4	PTEN
Description		H2A clustered histone 4	phosphatase and tensin homolog
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome CENP-A Containing Nucleosome Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Synapse
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Enzyme Binding PDZ Domain Binding Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding Ubiquitin Ligase Activator Activity
	Biological Process	Chromatin Organization Negative Regulation Of Cell Population Proliferation Heterochromatin Formation Protein Localization To CENP-A Containing Chromatin	Osteoblast Differentiation Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Spindle Assembly Involved In Female Meiosis Neuron-neuron Synaptic Transmission Nervous System Development Synapse Assembly Central Nervous System Development Heart Development Learning Or Memory Locomotory Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Migration Adult Behavior Regulation Of Protein Stability Central Nervous System Myelin Maintenance Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Social Behavior Maternal Behavior Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Locomotor Rhythm Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Phosphatidylinositol Dephosphorylation Forebrain Morphogenesis Cell Motility Negative Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Keratinocyte Migration Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission Synapse Maturation Prepulse Inhibition Dendritic Spine Morphogenesis Regulation Of Biological Quality Cellular Response To Electrical Stimulus Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2
Drugs			Phosphatidylethanolamine
Diseases			Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma
GWAS			Alanine aminotransferase levels ( 33547301) Ambidextrousness ( 32989287) Birth weight ( 31043758) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fasting insulin ( 34059833) Height ( 31562340) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 32888494) Plateletcrit ( 32888494) Psoriasis ( 28537254) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Thyroid stimulating hormone levels ( 32769997 30367059) Type 2 diabetes ( 32499647 24509480) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		49 interacting genes: ACE2 ANAPC11 BAP1 BARD1 BMI1 BRCA1 CDK1 CDK2 CHD4 COMMD4 CREBBP DTX3L EIF2AK2 EP300 EZH2 FANCD2 H2BC15 KAT2A KAT2B KAT5 KMT2A KMT2C KMT2D MAP4K1 MYB PCGF1 PRMT5 PSMD4 PTEN RAD18 RING1 RNF168 RNF169 RNF2 RNF20 RNF40 RNF8 RPL6 TP53BP1 TRIM37 TSPYL5 UBE2D3 UBE2N UFL1 UHRF1 USP16 USP2 USP22 USP51	376 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARMCX3 ASCC3 ATM ATP5F1A ATP5F1C BCAR1 BEX1 BGLT3 BUB3 CACTIN-AS1 CAD CALM1 CAMK2G CAV1 CBL CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COPA COPB1 COPS6 CREB1 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 CXXC1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EML1 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FLNA FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 H2AX HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDC1 MDN1 METTL26 MEX3C MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NDFIP1 NEDD4 NGB NHERF1 NHERF2 NOP56 NOP58 NPM3 NUMB OSGIN1 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB1 PHB2 PICK1 PIK3R1 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RNF31 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 RYBP S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SHARPIN SHROOM3 SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SMURF1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPOP SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TNPO3 TP53 TP53BP1 TRIM25 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2I UBE2L3 UPF1 USP7 USP9X UTP14A UTRN WWP1 WWP2 XRCC5 XRCC6 YAF2 YAP1 YES1 YTHDC2 YTHDF2 ZNF326
Entrez ID		8335	5728
HPRD ID		09105	03431
Ensembl ID		ENSG00000278463	ENSG00000171862
Uniprot IDs		P04908 Q08AJ9	F6KD01 P60484
PDB IDs		2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6USJ 6V2K 6V92 6YOV 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7DBP 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7SCY 7SCZ 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7ZI4 8G57 8GRM 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HQY 8HR1 8I17 8IEG 8IEJ 8IHL 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8Q36 8Q3E 8Q3M 8Q3X 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8W9D 8W9E 8W9F 8WG5 8X7I 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 8YV8 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ 7JTX 7JUK 7JUL 7JVX 7PC7 8X3S
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Transferase Activity Regulation Of Cell Cycle Chromatin Binding Nucleus DNA Repair Regulation Of Primary Metabolic Process DNA Damage Response Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Regulation Of Gene Expression Regulation Of Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Repair Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Transcription Coactivator Activity Histone Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of DNA Metabolic Process Protein Ubiquitination	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Macromolecule Metabolic Process Translation Nucleolus Nucleoplasm Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cytosol Nucleus Cytosolic Large Ribosomal Subunit Cytoplasm RNA Metabolic Process Extracellular Exosome Focal Adhesion RRNA Metabolic Process Protein Metabolic Process Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of DNA Metabolic Process Protein Binding Small Ribosomal Subunit ATP Binding Chromosome, Telomeric Region ATP Hydrolysis Activity Small-subunit Processome Positive Regulation Of DNA Biosynthetic Process RRNA Processing Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ribosomal Small Subunit Biogenesis MRNA Metabolic Process Nucleotide Binding DNA Metabolic Process Protein Localization To Organelle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus ATP-dependent Protein Folding Chaperone Positive Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Via Telomerase Chromosome Cadherin Binding
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