HIST1H2AB and UHRF1

Number of citations of the paper that reports this interaction (PMID 14993289)
51

Data Source:
HPRD (in vitro, in vivo)

		HIST1H2AB	UHRF1
Gene Name		histone cluster 1, H2ab	ubiquitin-like with PHD and ring finger domains 1
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Nuclear Chromatin Euchromatin Heterochromatin Nucleus Replication Fork Nuclear Matrix
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Ligase Activity Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity
	Biological Process	Biological_process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Transcription, DNA-templated Cell Cycle Cell Proliferation Maintenance Of DNA Methylation Histone Monoubiquitination Gene Expression Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Epigenetic regulation of gene expression DNA methylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BRCA1 CDK1 CDK2 EP300 ERCC6 KAT2B RNF2 UHRF1 USP16	22 interactors: BTRC DNMT1 DNMT3A H3F3A H3F3B HIST1H2AB HIST1H2BB HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST3H3 KAT5 MBD4 PARP1 PRKACA
Entrez ID		8335	29128
HPRD ID		09105	06992
Ensembl ID		ENSG00000137259
Uniprot IDs		P04908 Q08AJ9	Q96T88
PDB IDs		2CV5 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5
Enriched GO Terms of Interacting Partners?		Histone Modification Chromatin Modification Chromatin Organization Cell Cycle Cellular Response To DNA Damage Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Peptidyl-lysine Acetylation Nucleobase-containing Compound Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Centrosome Cycle Cellular Nitrogen Compound Metabolic Process Cellular Protein Modification Process DNA Repair Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Centrosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Organizing Center Organization N-terminal Protein Amino Acid Acetylation Signal Transduction By P53 Class Mediator Cellular Protein Metabolic Process Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint	DNA Methylation On Cytosine Chromatin Silencing At RDNA DNA Modification Chromatin Silencing DNA Methylation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Methylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Assembly Chromosome Organization Negative Regulation Of Gene Expression Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Organization Protein-DNA Complex Assembly DNA Packaging Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Regulation Of Body Fluid Levels DNA Conformation Change Wound Healing Regulation Of Gene Silencing Response To Wounding Gene Expression Cellular Macromolecular Complex Assembly Organelle Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Complex Assembly Nitrogen Compound Metabolic Process Response To Stress Regulation Of Gene Expression Cellular Component Assembly Regulation Of Metabolic Process
Tagcloud ?			24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Difference) ?			24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Intersection) ?