HIST1H2AB

Gene Name		histone cluster 1, H2ab
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Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Heterodimerization Activity
	Biological Process	Biological_process
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: BRCA1 CDK1 CDK2 EP300 ERCC6 KAT2B RNF2 UHRF1 USP16
Entrez ID		8335
HPRD ID		09105
Ensembl ID		ENSG00000137259
Uniprot IDs		P04908 Q08AJ9
PDB IDs		2CV5 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99
Enriched GO Terms of Interacting Partners?		Histone Modification Chromatin Modification Chromatin Organization Cell Cycle Cellular Response To DNA Damage Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Peptidyl-lysine Acetylation Nucleobase-containing Compound Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Centrosome Cycle Cellular Nitrogen Compound Metabolic Process Cellular Protein Modification Process DNA Repair Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Centrosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Organizing Center Organization N-terminal Protein Amino Acid Acetylation Signal Transduction By P53 Class Mediator Cellular Protein Metabolic Process Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint
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