H2AC4 and CREBBP

Number of citations of the paper that reports this interaction (PubMedID 12665567)
56

Data Source:
BioGRID (enzymatic study)

		H2AC4	CREBBP
Description		H2A clustered histone 4	CREB binding lysine acetyltransferase
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome CENP-A Containing Nucleosome Extracellular Exosome	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Transcription Coactivator Binding P53 Binding Chromatin Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Chromatin DNA Binding MRF Binding Histone H3K18 Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity DNA-binding Transcription Factor Binding
	Biological Process	Chromatin Organization Negative Regulation Of Cell Population Proliferation Heterochromatin Formation Protein Localization To CENP-A Containing Chromatin	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase I N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Cellular Response To Nutrient Levels Cellular Response To UV Homeostatic Process Embryonic Digit Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Protein-containing Complex Assembly Protein K48-linked Deubiquitination Energy Homeostasis Regulation Of Cellular Response To Heat Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Regulation of gene expression by Hypoxia-inducible Factor BMAL1:CLOCK,NPAS2 activates circadian expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1 Heme signaling Nuclear events mediated by NFE2L2 NPAS4 regulates expression of target genes Formation of paraxial mesoderm NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Zygotic genome activation (ZGA) Evasion by RSV of host interferon responses MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Colforsin 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases			Rubinstein-Taybi syndrome
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Neutrophil count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Pre-treatment viral load in HIV-1 infection ( 31219150) QT interval ( 24952745) QT interval (drug interaction) ( 23459443) White blood cell count ( 32888494)
Interacting Genes		49 interacting genes: ACE2 ANAPC11 BAP1 BARD1 BMI1 BRCA1 CDK1 CDK2 CHD4 COMMD4 CREBBP DTX3L EIF2AK2 EP300 EZH2 FANCD2 H2BC15 KAT2A KAT2B KAT5 KMT2A KMT2C KMT2D MAP4K1 MYB PCGF1 PRMT5 PSMD4 PTEN RAD18 RING1 RNF168 RNF169 RNF2 RNF20 RNF40 RNF8 RPL6 TP53BP1 TRIM37 TSPYL5 UBE2D3 UBE2N UFL1 UHRF1 USP16 USP2 USP22 USP51	364 interacting genes: ACSS1 ACTA2 ACTB ACVR1 AFP AIRE AKT1 ALX1 ANAPC5 ANAPC7 ANKS1A ANKS1B ANXA7 AP1B1 APC APP AR ATF1 ATF3 ATF4 ATF7IP ATRX BAG5 BCL3 BCL6 BRCA1 BRIP1 CALCOCO1 CAMK4 CAMSAP2 CARM1 CASP8AP2 CBX4 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CEP290 CHAF1A CHD3 CHRDL1 CHUK CIITA CITED1 CITED2 CLASP2 CNOT3 CNTRL CPAP CPSF4 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK E2F1 E2F5 EBF1 EEF1A1 EEF2 EGR1 EID1 EID3 EIF2B1 EIF3D EIF4G2 ELF3 ELK1 EP300 EPG5 ESR1 ETS1 ETS2 EWSR1 EXOC5 FAF1 FBXL19 FBXO38 FGFR1 FHL2 FOXH1 FOXM1 FOXO1 FOXO3 FOXO4 FUS GAA GABPA GAK GATA1 GATAD2A GCM1 GLI3 GMEB1 GMEB2 GPR161 GRIA3 GSTO2 GTF2B H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H4C16 HBP1 HCK HDAC1 HDAC3 HEXA HIF1A HIPK1 HIPK2 HIPK3 HIVEP1 HIVEP2 HLF HMG20A HMGA1 HMGB1 HMGB2 HMGXB4 HNF1A HNF1B HNF4A HNRNPL HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT HUWE1 IKBKG IQGAP1 IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM2B KDM3B KDM6A KDM6B KHDRBS1 KIF5A KISS1 KLF1 KLF13 KLF4 KLF5 KMT2A KMT2D KPNA2 KPNA6 LATS1 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP1B MAP3K5 MAPK1 MAPK10 MAPK3 MAPT MARK2 MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MOB1A MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYO1E MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 OGT ONECUT1 PAPPA PAX5 PBX1 PCMT1 PCNA PELP1 PHLDA1 PHOX2A PIAS1 PIAS2 PIAS3 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARGC1A PPP1R8 PPP2R2A PRKCD PRKCZ PRLR PROX1 PSME3 PTMA PTPRF RAD23A RAD50 RBBP4 RBBP7 RBCK1 RBM24 RBM5 RELA RFK RNF111 RNF7 RPL3 RPL35 RPS20 RPS6KA1 RPS6KA3 RPS6KA5 RXRG SEMA3B SEPTIN3 SERTAD1 SERTAD2 SERTAD3 SETDB1 SH3GL1 SHCBP1 SLC1A4 SMAD1 SMAD2 SMAD3 SMAD4 SNAI1 SNAI2 SNAPC5 SND1 SNIP1 SNRNP200 SOS2 SOX9 SP100 SPI1 SPIB SPTAN1 SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUMO1 SUV39H1 SYT1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TIAL1 TIAM1 TOPORS TP53 TP53BP2 TP73 TRERF1 TRIM24 TRIP10 TRIP4 TSPYL2 TUBB UBE2D1 UBE2I UBTF UIMC1 VAT1L VDR WAS WDR77 WT1 XAF1 XRCC6 YTHDF2 YWHAH YY1 ZBTB17 ZBTB2 ZCCHC7 ZHX1 ZMYM2 ZMYM5 ZNF106 ZNF451 ZNF639 ZNFX1
Entrez ID		8335	1387
HPRD ID		09105	02534
Ensembl ID		ENSG00000278463	ENSG00000005339
Uniprot IDs		P04908 Q08AJ9	Q92793
PDB IDs		2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6USJ 6V2K 6V92 6YOV 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7DBP 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7SCY 7SCZ 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7ZI4 8G57 8GRM 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HQY 8HR1 8I17 8IEG 8IEJ 8IHL 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8Q36 8Q3E 8Q3M 8Q3X 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8W9D 8W9E 8W9F 8WG5 8X7I 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 8YV8 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2N1A 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP 5DBM 5EIC 5ENG 5EP7 5GH9 5H85 5I83 5I86 5I89 5I8B 5I8G 5J0D 5JEM 5KTU 5KTW 5KTX 5LPJ 5LPL 5MME 5MMG 5MPK 5MPN 5MPZ 5MQE 5MQG 5MQK 5NLK 5NRW 5NU3 5OWK 5SVH 5TB6 5W0E 5W0F 5W0L 5W0Q 5XXH 6ALB 6ALC 6AXQ 6AY3 6AY5 6DMK 6ES5 6ES6 6ES7 6FQO 6FQT 6FQU 6FR0 6FRF 6LQX 6M64 6QST 6SQE 6SQF 6SQM 6SXX 6YIJ 6YIK 6YIL 6YIM 7CO1 7EVJ 7JFL 7JFM 7JUO 7KPY 7RLE 7TB3 7TBH 7UGE 7UGL 7WX2 7XH6 7XHE 7XI0 7XIJ 7XM7 7XNE 7XNG 8FUP 8FV2 8FXA 8FXE 8FXN 8FXO 8G6T 8GA2 8HAL 8HAM 8HAN 9J6O 9JUU 9JUY
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Transferase Activity Regulation Of Cell Cycle Chromatin Binding Nucleus DNA Repair Regulation Of Primary Metabolic Process DNA Damage Response Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Regulation Of Gene Expression Regulation Of Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Repair Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Transcription Coactivator Activity Histone Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of DNA Metabolic Process Protein Ubiquitination	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin DNA Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Transcription Regulator Complex Chromatin Binding DNA-templated Transcription Regulation Of Developmental Process Cellular Developmental Process Regulation Of Cell Differentiation RNA Polymerase II Transcription Regulator Complex Cell Differentiation DNA-binding Transcription Factor Binding Developmental Process Chromatin Organization
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