EXOC4 and DLG3

Number of citations of the paper that reports this interaction (PMID 12738960)
70

Data Source:
HPRD (two hybrid, in vitro)

		EXOC4	DLG3
Gene Name		exocyst complex component 4	discs, large homolog 3 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane
	Molecular Function	Protein Binding Ral GTPase Binding PDZ Domain Binding Protein N-terminus Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing	Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tonometry ( 17903302)
Protein-Protein Interactions		10 interactors: BIRC6 CEP63 DISC1 DLG3 DLG4 DLGAP4 DTNBP1 EXOC7 GRIN2B RALA	40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		60412	1741
HPRD ID		12185	02177
Ensembl ID		ENSG00000131558	ENSG00000082458
Uniprot IDs		B7Z321 F5GZT1 Q6NX51 Q96A65	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Membrane Organization Cell-cell Signaling Protein Localization To Synapse Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Organelle Organization Synaptic Transmission Chemotaxis Locomotion Neuron Projection Morphogenesis Cellular Localization Movement Of Cell Or Subcellular Component Receptor Clustering Generation Of Neurons Regulation Of Synaptic Transmission Neuron Projection Development Nucleotide Phosphorylation Cell Projection Morphogenesis Signaling Cell Part Morphogenesis Neurogenesis Exocytosis Cell Communication Actin Cytoskeleton Reorganization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron Development Axon Guidance Post-Golgi Vesicle-mediated Transport Cell Division Cell Morphogenesis Neuron Differentiation Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Secretion By Cell Membrane Depolarization Axonogenesis Neuromuscular Process Nervous System Development Axon Development Learning Cell Morphogenesis Involved In Neuron Differentiation Membrane Raft Localization Actin Cytoskeleton Organization Secretion Actin Filament-based Process Vesicle-mediated Transport Regulation Of Synaptic Plasticity	Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization
Tagcloud ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?