EXOC4

Description		exocyst complex component 4
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GO Annotations	Cellular Component	Exocyst Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region Cell Projection Neuron Projection Synapse Flemming Body
	Molecular Function	Protein Binding PDZ Domain Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Chemical Synaptic Transmission Protein Transport Regulation Of Macroautophagy Paraxial Mesoderm Formation Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease (cognitive decline) ( 23535033) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Food allergy ( 29030101) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Moderate to vigorous physical activity levels ( 29899525) Mood instability ( 31168069) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) QT interval ( 29213071) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Subcortical volume (MOSTest) ( 32665545) Tonometry ( 17903302) Vigorous physical activity ( 29899525)
Novel Interacting Genes		1 novel interacting genes: DHFR
Interacting Genes		16 interacting genes: BIRC6 CCHCR1 CEP63 DISC1 DLG3 DLG4 DLGAP4 EXOC7 GOLGA1 GRIN2B ING1 MBD3 RALA SMARCE1 TTC3 WEE2-AS1
Entrez ID		60412
HPRD ID		12185
Ensembl ID		ENSG00000131558
Uniprot IDs		Q6NX51 Q96A65
PDB IDs		7PC5
Enriched GO Terms of Interacting Partners?		Flemming Body Synaptic Membrane Neuromuscular Junction Microtubule Organizing Center Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Excitatory Postsynaptic Potential Response To Methotrexate Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Receptor Localization To Synapse P2Y1 Nucleotide Receptor Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Molecular Adaptor Activity Protein Localization To Synapse Regulation Of Neuronal Synaptic Plasticity
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