EXOC4 and RALA

Number of citations of the paper that reports this interaction (PMID 11406615)
35

Data Source:
HPRD (in vitro)

		EXOC4	RALA
Gene Name		exocyst complex component 4	v-ral simian leukemia viral oncogene homolog A (ras related)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ral GTPase Binding PDZ Domain Binding Protein N-terminus Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization	Cytokinesis Exocytosis Chemotaxis Signal Transduction Ras Protein Signal Transduction Viral Process Regulation Of Exocytosis Actin Cytoskeleton Reorganization Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing	Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events Translocation of GLUT4 to the plasma membrane NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tonometry ( 17903302)
Protein-Protein Interactions		10 interactors: BIRC6 CEP63 DISC1 DLG3 DLG4 DLGAP4 DTNBP1 EXOC7 GRIN2B RALA	32 interactors: ARF1 CALM1 CNKSR2 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA HRAS LRPAP1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RAP1A RAP2A RAP2B RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3
Entrez ID		60412	5898
HPRD ID		12185	01549
Ensembl ID		ENSG00000131558	ENSG00000006451
Uniprot IDs		B7Z321 F5GZT1 Q6NX51 Q96A65	P11233
PDB IDs			1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Membrane Organization Cell-cell Signaling Protein Localization To Synapse Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Organelle Organization Synaptic Transmission Chemotaxis Locomotion Neuron Projection Morphogenesis Cellular Localization Movement Of Cell Or Subcellular Component Receptor Clustering Generation Of Neurons Regulation Of Synaptic Transmission Neuron Projection Development Nucleotide Phosphorylation Cell Projection Morphogenesis Signaling Cell Part Morphogenesis Neurogenesis Exocytosis Cell Communication Actin Cytoskeleton Reorganization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron Development Axon Guidance Post-Golgi Vesicle-mediated Transport Cell Division Cell Morphogenesis Neuron Differentiation Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Secretion By Cell Membrane Depolarization Axonogenesis Neuromuscular Process Nervous System Development Axon Development Learning Cell Morphogenesis Involved In Neuron Differentiation Membrane Raft Localization Actin Cytoskeleton Organization Secretion Actin Filament-based Process Vesicle-mediated Transport Regulation Of Synaptic Plasticity	Exocytosis Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Membrane Organization Secretion By Cell Intracellular Signal Transduction Secretion Ras Protein Signal Transduction Establishment Of Protein Localization Protein Localization Vesicle Docking Protein Transport Membrane Docking Rap Protein Signal Transduction Establishment Of Localization In Cell Cellular Localization Vesicle Docking Involved In Exocytosis Positive Regulation Of Protein Autophosphorylation Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Transport Regulation Of Protein Autophosphorylation Organelle Organization Regulation Of Signal Transduction Golgi Vesicle Transport Exocyst Localization Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cellular Protein Complex Localization Blood Coagulation Cell Communication Positive Regulation Of Ras GTPase Activity Hemostasis Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Protein Complex Localization Cellular Response To Stimulus Regulation Of Cell Projection Organization Regulation Of GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Body Fluid Levels Wound Healing Golgi To Plasma Membrane Transport
Tagcloud ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Difference) ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncr1 ncrs nk nkp46 partly proto ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Intersection) ?