EXOC4 and GRIN2B

Number of citations of the paper that reports this interaction (PMID 12738960)
70

Data Source:
HPRD (in vivo)

		EXOC4	GRIN2B
Gene Name		exocyst complex component 4	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Protein Binding Ral GTPase Binding PDZ Domain Binding Protein N-terminus Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing	EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tonometry ( 17903302)	Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)
Protein-Protein Interactions		10 interactors: BIRC6 CEP63 DISC1 DLG3 DLG4 DLGAP4 DTNBP1 EXOC7 GRIN2B RALA	40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		60412	2904
HPRD ID		12185	00697
Ensembl ID		ENSG00000131558
Uniprot IDs		B7Z321 F5GZT1 Q6NX51 Q96A65	Q13224
PDB IDs			1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Membrane Organization Cell-cell Signaling Protein Localization To Synapse Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Organelle Organization Synaptic Transmission Chemotaxis Locomotion Neuron Projection Morphogenesis Cellular Localization Movement Of Cell Or Subcellular Component Receptor Clustering Generation Of Neurons Regulation Of Synaptic Transmission Neuron Projection Development Nucleotide Phosphorylation Cell Projection Morphogenesis Signaling Cell Part Morphogenesis Neurogenesis Exocytosis Cell Communication Actin Cytoskeleton Reorganization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron Development Axon Guidance Post-Golgi Vesicle-mediated Transport Cell Division Cell Morphogenesis Neuron Differentiation Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Secretion By Cell Membrane Depolarization Axonogenesis Neuromuscular Process Nervous System Development Axon Development Learning Cell Morphogenesis Involved In Neuron Differentiation Membrane Raft Localization Actin Cytoskeleton Organization Secretion Actin Filament-based Process Vesicle-mediated Transport Regulation Of Synaptic Plasticity	Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation
Tagcloud ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		adt androgen arap2 clinicopathologic cumulative dab2 deprivation frk genotypes kaplan meier pcsm prediction predictor predictors prostate prostatectomy radical remained rs1149558 rs1444377 rs171866 rs268091 rs722740 snps systematically tp53 trps1 valuable	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?