EXOC4 and TTC3

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		EXOC4	TTC3
Name		exocyst complex component 4	tetratricopeptide repeat domain 3
Structure			No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region Cell Projection Neuron Projection Synapse Flemming Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding PDZ Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Chemical Synaptic Transmission Protein Transport Regulation Of Macroautophagy Paraxial Mesoderm Formation Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	None
GWAS		Age at first sexual intercourse ( 34211149 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Extremely high intelligence ( 29520040 ) Food allergy ( 29030101 ) Fruit consumption ( 32066663 ) General cognitive ability ( 29844566 ) Household income (MTAG) ( 31844048 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Moderate to vigorous physical activity levels ( 29899525 ) Mood instability ( 31168069 ) Peanut allergy ( 29030101 ) Plasma anti-thyroid peroxidase levels ( 29678681 ) QT interval ( 29213071 ) Response to selective serotonin reuptake inhibitors in depression ( 30034349 ) Subcortical volume (MOSTest) ( 32665545 ) Tonometry ( 17903302 ) Vigorous physical activity ( 29899525 )	Eye color traits ( 20463881 )
Novel Interactors		1 novel interactors: DHFR	3 novel interactors: DSCAM KCNJ15 PCP4
Interacting Genes		16 interacting genes: BIRC6 CCHCR1 CEP63 DISC1 DLG3 DLG4 DLGAP4 EXOC7 GOLGA1 GRIN2B ING1 MBD3 RALA SMARCE1 TTC3 WEE2-AS1	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		60412	7267
HPRD ID		12185	03773
Ensembl ID		ENSG00000131558	ENSG00000182670
Uniprot IDs		Q6NX51 Q96A65	H7BZ57 P53804
PDB IDs		7PC5	Not available
GO Terms Enriched among Interactors		Flemming Body Synaptic Membrane Neuromuscular Junction Microtubule Organizing Center Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Excitatory Postsynaptic Potential Response To Methotrexate Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Receptor Localization To Synapse P2Y1 Nucleotide Receptor Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Molecular Adaptor Activity Protein Localization To Synapse Regulation Of Neuronal Synaptic Plasticity	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex