RALGDS and CD68

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RALGDS	CD68
Gene Name		ral guanine nucleotide dissociation stimulator	CD68 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Brush Border	Lysosomal Membrane Plasma Membrane Endosome Membrane Membrane Integral Component Of Membrane
	Molecular Function	Small GTPase Regulator Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Cellular Response To Organic Substance
Pathways		Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MLLT4 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	2 interactors: ADRB2 RALGDS
Entrez ID		5900	968
HPRD ID		03371	01093
Ensembl ID		ENSG00000160271	ENSG00000129226
Uniprot IDs		B7Z753 E7ER93 E7ERZ0 Q12967 Q6PCE1 Q6ZSD5 Q8N4Y1	P34810
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Rap GTPase Activity Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Blood Coagulation Regulation Of Phosphorus Metabolic Process Hemostasis Positive Regulation Of Protein Modification Process Signaling Cellular Response To Stimulus Cell Communication Platelet Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synaptic Transmission Response To Wounding Regulation Of Protein Kinase Activity Establishment Of Endothelial Barrier Response To Stimulus Regulation Of GTPase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Epithelial Cell Development Regulation Of Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Heat Generation Diet Induced Thermogenesis Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Dietary Excess Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Temperature Homeostasis Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Vasodilation Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Brown Fat Cell Differentiation Lysosomal Transport Regulation Of Vasodilation Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Positive Regulation Of Catalytic Activity Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Response To Cold Bone Remodeling Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Positive Regulation Of CAMP Metabolic Process Regulation Of Bone Mineralization Regulation Of Blood Vessel Size Regulation Of Tube Size Vacuolar Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Developmental Growth Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Ossification Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Binding
Tagcloud ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	1beta 1ra antiinflammatory bmmc ccf cd11b cd14 cd16 cd64 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Difference) ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	1beta 1ra antiinflammatory bmmc ccf cd11b cd14 cd16 cd64 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Intersection) ?