RALGDS and RAP2B

Number of citations of the paper that reports this interaction (PMID 10085114)
9

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		RALGDS	RAP2B
Gene Name		ral guanine nucleotide dissociation stimulator	RAP2B, member of RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Brush Border	Cytosol Plasma Membrane Tight Junction Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Small GTPase Regulator Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTP Binding GDP Binding Protein Domain Specific Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier
Pathways		Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MLLT4 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	8 interactors: CAMK2B PDE6D RALA RALGDS RAPGEF2 RAPGEF5 RASSF5 RUNDC3A
Entrez ID		5900	5912
HPRD ID		03371	01548
Ensembl ID		ENSG00000160271
Uniprot IDs		B7Z753 E7ER93 E7ERZ0 Q12967 Q6PCE1 Q6ZSD5 Q8N4Y1	P61225
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Rap GTPase Activity Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Blood Coagulation Regulation Of Phosphorus Metabolic Process Hemostasis Positive Regulation Of Protein Modification Process Signaling Cellular Response To Stimulus Cell Communication Platelet Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synaptic Transmission Response To Wounding Regulation Of Protein Kinase Activity Establishment Of Endothelial Barrier Response To Stimulus Regulation Of GTPase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Epithelial Cell Development Regulation Of Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process	Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Ras Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cell Projection Organization Signal Transduction Response To Stimulus Regulation Of Dendrite Morphogenesis Signaling Cell Communication Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Regulation Of Dendrite Development Negative Regulation Of Melanin Biosynthetic Process Activation Of Meiosis Involved In Egg Activation Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Raft Localization Activation Of Meiosis Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of GTPase Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Metabolic Process Positive Regulation Of Neuron Projection Development Response To CGMP Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Rap Protein Signal Transduction Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Hydrolase Activity Positive Regulation Of Vasculogenesis
Tagcloud ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak
Tagcloud (Difference) ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak
Tagcloud (Intersection) ?