RALGDS and RIT2

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (two hybrid)

		RALGDS	RIT2
Gene Name		ral guanine nucleotide dissociation stimulator	Ras-like without CAAX 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Brush Border	Nucleus Plasma Membrane
	Molecular Function	Small GTPase Regulator Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Calmodulin Binding GTP Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway
Pathways		Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane	Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-Protein Interactions		23 interactors: ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MLLT4 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		5900	6014
HPRD ID		03371	15253
Ensembl ID		ENSG00000160271	ENSG00000152214
Uniprot IDs		B7Z753 E7ER93 E7ERZ0 Q12967 Q6PCE1 Q6ZSD5 Q8N4Y1	Q99578
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Rap GTPase Activity Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Blood Coagulation Regulation Of Phosphorus Metabolic Process Hemostasis Positive Regulation Of Protein Modification Process Signaling Cellular Response To Stimulus Cell Communication Platelet Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synaptic Transmission Response To Wounding Regulation Of Protein Kinase Activity Establishment Of Endothelial Barrier Response To Stimulus Regulation Of GTPase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Epithelial Cell Development Regulation Of Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity
Tagcloud ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Difference) ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Intersection) ?