RALGDS and RIN1

Number of citations of the paper that reports this interaction (PubMedID 10545207)
0

Data Source:
BioGRID (two hybrid)

		RALGDS	RIN1
Description		ral guanine nucleotide dissociation stimulator	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Brush Border	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Endocytosis Signal Transduction Vesicle-mediated Transport Intracellular Signal Transduction
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	49 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP ITSN1 KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		5900	9610
HPRD ID		03371	05813
Ensembl ID		ENSG00000160271	ENSG00000174791
Uniprot IDs		Q12967 Q8N4Y1	A0A0S2Z4T5 A0A0S2Z4U0 Q13671
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Ras Protein Signal Transduction Rap Protein Signal Transduction GTP Binding Intracellular Signal Transduction Plasma Membrane Signal Transduction Regulation Of MAPK Cascade Establishment Of Endothelial Barrier Regulation Of Vesicle-mediated Transport Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Component Organization Epithelial Cell Development Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Microvillus Assembly Nucleotide Binding Positive Regulation Of Vasculogenesis Regulation Of Cell Migration MAPK Cascade Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Motility Regulation Of Vasculogenesis Angiotensin Receptor Binding Regulation Of Locomotion Cell Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Schwann Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Signal Transduction Membrane Hydrolase Activity Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Migration Positive Regulation Of Microvillus Assembly Positive Regulation Of Cell Motility Regulation Of Cell Projection Assembly Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Anchoring Junction Actin Filament-based Process Desensitization Of G Protein-coupled Receptor Signaling Pathway	Cytosol Cytoplasm Perinuclear Region Of Cytoplasm Phosphoserine Residue Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade ERBB Signaling Pathway GDP Binding Intracellular Signaling Cassette MAPK Cascade Identical Protein Binding Regulation Of Intracellular Signal Transduction Protein Sequestering Activity ERBB3:ERBB2 Complex Regulation Of Autophagy Melanosome Positive Regulation Of Intracellular Signal Transduction Cellular Localization Vesicle-mediated Transport Schwann Cell Development Protein Tyrosine Kinase Activity Glial Cell Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Protein Localization Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Establishment Of Localization In Cell Regulation Of Cell Communication Signal Transduction Regulation Of Signaling ErbB-3 Class Receptor Binding Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Actin Filament-based Process Protein Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Signal Transduction Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Phosphatase Binding Myelination Axon Ensheathment Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERBB2-EGFR Signaling Pathway
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