RHEB and PSEN2

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		RHEB	PSEN2
Description		Ras homolog, mTORC1 binding	presenilin 2
Image
GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving
	Biological Process	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases			Alzheimer's disease (AD)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)	Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4	61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1
Entrez ID		6009	5664
HPRD ID		03188	02860
Ensembl ID		ENSG00000106615	ENSG00000143801
Uniprot IDs		A0A090N900 Q15382	P49810
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD	7Y5X 7Y5Z
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction	Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation
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