RHEB

Gene Name		Ras homolog enriched in brain
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of TOR Signaling
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-protein Interactions		22 interactors: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF ECSIT FKBP8 MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RPS6KB1 RPTOR TSC1 TSC2
Entrez ID		6009
HPRD ID		03188
Ensembl ID		ENSG00000106615
Uniprot IDs		Q15382
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Signaling Cell Communication Regulation Of Signal Transduction Response To Stress Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Peptide Hormone Insulin Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Metabolic Process Response To Insulin Response To Peptide Cell Differentiation Regulation Of Protein Kinase Activity Response To External Stimulus Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Heat Cellular Response To Insulin Stimulus Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Developmental Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Immune System Process Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Cell Development Regulation Of Cell Size Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cellular Component Organization Regulation Of Cell Death Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Negative Regulation Of Cell Size Cellular Response To Peptide Cellular Response To Heat Cellular Response To Growth Factor Stimulus Neural Tube Development
Tagcloud ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded