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RHEB and TSC2
Number of citations of the paper that reports this interaction (PubMedID
30514904
)
58
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
HPRD
(in vitro)
RHEB
TSC2
Description
Ras homolog, mTORC1 binding
TSC complex subunit 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Spliceosomal Complex
Cytoplasm
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Endomembrane System
Postsynaptic Density
Membrane
Synapse
Extracellular Exosome
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein Kinase Binding
Protein Kinase Activator Activity
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Autophagosome Assembly
Cytoplasmic Translation
Signal Transduction
Small GTPase-mediated Signal Transduction
Response To Virus
Negative Regulation Of Autophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Regulation Of TOR Signaling
Positive Regulation Of TOR Signaling
TORC1 Signaling
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Cell Cycle
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of TORC1 Signaling
Regulation Of Type B Pancreatic Cell Development
Neural Tube Closure
Cytoplasmic Translation
Protein Import Into Nucleus
Endocytosis
Heart Development
Intracellular Protein Localization
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
TORC1 Signaling
Anoikis
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Mitophagy
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Carboplatin disposition in epthelial ovarian cancer (
29367611
)
Metabolite levels (
23823483
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
29 interacting genes:
A2M
APOE
APPBP2
ARIH2
ATM
ATR
BNIP3
BNIP3L
BRAF
CREB3
ECSIT
FKBP8
HTT
MTOR
NCAM1
PDE6D
PLD1
PSEN1
PSEN2
RABAC1
RAF1
RNF152
RPS6KB1
RPTOR
TRIM55
TRIM63
TSC1
TSC2
USP4
61 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
BTG3
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP1CA
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
6009
7249
HPRD ID
03188
01850
Ensembl ID
ENSG00000106615
ENSG00000103197
Uniprot IDs
A0A090N900
Q15382
A0A2R8Y6C9
A0A2R8YDZ2
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D2U8
X5D7Q2
PDB IDs
1XTQ
1XTR
1XTS
3SEA
3T5G
5YXH
6BCU
6BSX
6BT0
7BTA
7BTC
7BTD
7DL2
9CE3
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Autophagy
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
TORC1 Signaling
TOR Signaling
Negative Regulation Of TOR Signaling
Regulation Of TOR Signaling
Positive Regulation Of Translational Initiation
Positive Regulation Of TOR Signaling
Response To Nutrient Levels
Positive Regulation Of Autophagy
Regulation Of Macroautophagy
Response To Stress
Positive Regulation Of Catabolic Process
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Translation
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Translational Initiation
Cellular Response To Nutrient Levels
Regulation Of Autophagy Of Mitochondrion
Regulation Of Translational Initiation
Protein Metabolic Process
Apoptotic Process
Positive Regulation Of Cell Communication
Programmed Cell Death
Cell Death
Cytoplasmic Translation
Response To Starvation
Signal Transduction
Intracellular Signaling Cassette
Negative Regulation Of Apoptotic Process
Golgi Apparatus
Negative Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Autophagosome Assembly
Positive Regulation Of Metabolic Process
Positive Regulation Of Macroautophagy
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Autophagosome Organization
Regulation Of Apoptotic Process
Negative Regulation Of Autophagy
Regulation Of Mitophagy
Protein Catabolic Process
Thymus Development
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Phosphoserine Residue Binding
Regulation Of TOR Signaling
Cytosol
TOR Signaling
Negative Regulation Of TOR Signaling
Protein Kinase Binding
Cytoplasm
TORC1 Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Biological Quality
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Regulation Of Signal Transduction
Protein Domain Specific Binding
Macromolecule Metabolic Process
Cellular Response To Stress
Protein Sequestering Activity
Ciliary Basal Body
Identical Protein Binding
Insulin Receptor Signaling Pathway
Signal Transduction
Protein Kinase Activity
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Kinase Activity
Protein Phosphorylation
Protein Serine Kinase Activity
Regulation Of Synaptic Plasticity
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Organelle Organization
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Negative Regulation Of Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Cell Communication
Nucleus
Regulation Of Immune Response
Regulation Of Protein Metabolic Process
Protein Serine/threonine Kinase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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