RHEB and ARIH2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RHEB	ARIH2
Gene Name		Ras homolog enriched in brain	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Metal Ion Binding	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of TOR Signaling	Protein Polyubiquitination Multicellular Organismal Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF ECSIT FKBP8 MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RPS6KB1 RPTOR TSC1 TSC2	44 interactors: ARAP1 BUB1 CBR3 CCDC33 CUL5 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 KIAA1377 LOC147791 NEDD8 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		6009	10425
HPRD ID		03188	09286
Ensembl ID		ENSG00000106615	ENSG00000177479
Uniprot IDs		Q15382	O95376 Q6IBL8
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Signaling Cell Communication Regulation Of Signal Transduction Response To Stress Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Peptide Hormone Insulin Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Metabolic Process Response To Insulin Response To Peptide Cell Differentiation Regulation Of Protein Kinase Activity Response To External Stimulus Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Heat Cellular Response To Insulin Stimulus Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Developmental Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Immune System Process Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Cell Development Regulation Of Cell Size Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cellular Component Organization Regulation Of Cell Death Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Negative Regulation Of Cell Size Cellular Response To Peptide Cellular Response To Heat Cellular Response To Growth Factor Stimulus Neural Tube Development	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process ISG15-protein Conjugation Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Protein Monoubiquitination Cell Cycle Toll-like Receptor Signaling Pathway Mitotic Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Response To Stimulus Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Mitotic Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Immune Response Regulation Of Cell Cycle Phase Transition
Tagcloud ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Difference) ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded	aldo1 anxa2 cdna cerebral characterize coding cortical ddit3 egr1 endoplasmic ero1l fold gadd153 gas5 giig11 gpi1 hig1 hypoxia microarray ndr1 neuronal p4hb profiling reinforce repressed reticulum sac1p ubiquitination vdac2
Tagcloud (Intersection) ?