RHEB and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 17991864)
0

Data Source:
BioGRID (pull down, two hybrid)

		RHEB	FKBP8
Description		Ras homolog, mTORC1 binding	FKBP prolyl isomerase 8
Image
GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome	Mitochondrion Mitochondrial Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Calmodulin Binding Isomerase Activity Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development	Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Signal Transduction Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Gene Expression Dorsal/ventral Neural Tube Patterning Neural Tube Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Neuron Fate Specification Regulation Of Macromolecule Metabolic Process Protein Localization To Mitochondrion Regulation Of Mitophagy
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Ub-specific processing proteases
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4	52 interacting genes: AQP6 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BIK BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MTOR OGT PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SHANK3 SLC10A1 SLC10A6 SLC35A5 SLC35B1 SLC71A2 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1
Entrez ID		6009	23770
HPRD ID		03188	05327
Ensembl ID		ENSG00000106615	ENSG00000105701
Uniprot IDs		A0A090N900 Q15382	B2R8G6 Q14318
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD	2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Cellular Localization Mitochondrial Membrane Negative Regulation Of Catabolic Process Regulation Of Protein Localization Bcl-2 Family Protein Complex Protein Binding Transmembrane Transport Negative Regulation Of Autophagy Dendritic Cell Apoptotic Process Ascorbate Homeostasis Intracellular Signal Transduction Regulation Of Membrane Potential Transmembrane Monodehydroascorbate Reductase Activity Striated Muscle Cell Development Skeletal Muscle Fiber Development Bile Acid:sodium Symporter Activity Positive Regulation Of Growth Regulation Of Protein Catabolic Process BH3 Domain Binding Myotube Cell Development Regulation Of Establishment Of Protein Localization Muscle Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Signaling Cassette Regulation Of TORC1 Signaling Channel Activity ERBB2-EGFR Signaling Pathway Cell Morphogenesis Autophagy Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Striated Muscle Cell Differentiation Oligodendrocyte Differentiation Monoatomic Ion Transport Regulation Of Myotube Differentiation Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Translational Initiation Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Growth Positive Regulation Of Translational Initiation Mononuclear Cell Proliferation Nucleotide-sugar Transmembrane Transport Negative Regulation Of Calcium Ion Transport Identical Protein Binding Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Ciliary Membrane
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