RHEB and BNIP3L

Number of citations of the paper that reports this interaction (PMID 17928295)
45

Data Source:
BioGRID (two hybrid)

		RHEB	BNIP3L
Gene Name		Ras homolog enriched in brain	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome	Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Integral Component Of Membrane Intrinsic Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Metal Ion Binding	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of TOR Signaling	Viral Process Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Defense Response To Virus Mitochondrial Outer Membrane Permeabilization
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF ECSIT FKBP8 MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RPS6KB1 RPTOR TSC1 TSC2	23 interactors: BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 DOK5 DUSP3 ECM1 EWSR1 FATE1 GBP2 GNB5 KLHL23 LDLRAD1 MAP1LC3A RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11
Entrez ID		6009	665
HPRD ID		03188	07288
Ensembl ID		ENSG00000106615	ENSG00000104765
Uniprot IDs		Q15382	B0AZS9 B4DTN1 O60238 Q6IBV1
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Signaling Cell Communication Regulation Of Signal Transduction Response To Stress Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Peptide Hormone Insulin Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Metabolic Process Response To Insulin Response To Peptide Cell Differentiation Regulation Of Protein Kinase Activity Response To External Stimulus Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Heat Cellular Response To Insulin Stimulus Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Developmental Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Immune System Process Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Cell Development Regulation Of Cell Size Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cellular Component Organization Regulation Of Cell Death Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Negative Regulation Of Cell Size Cellular Response To Peptide Cellular Response To Heat Cellular Response To Growth Factor Stimulus Neural Tube Development	Mitochondrial Membrane Organization Mitochondrion Organization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Defense Response Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Death Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Response To External Stimulus Regulation Of Mitochondrion Organization Ovulation Cycle Process Negative Regulation Of Anoikis Positive Regulation Of Apoptotic Process Regulation Of Autophagy Female Gonad Development Positive Regulation Of Programmed Cell Death Ovulation Cycle Regulation Of Anoikis Development Of Primary Female Sexual Characteristics Positive Regulation Of Cell Death Regulation Of Response To DNA Damage Stimulus Response To Stress Defense Response To Protozoan Regulation Of Signal Transduction Response To Protozoan Response To Other Organism Release Of Cytochrome C From Mitochondria Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Biotic Stimulus Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitochondrion Organization Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Regulation Of Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Cellular Response To Organic Substance Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Calcium Ion Transport Membrane Organization Negative Regulation Of Calcium Ion Transport Cell Communication Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process
Tagcloud ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded	abrogates autophagy carried connections endoplasmic er extent hct116 interest ire1 microarray nbr1 nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation
Tagcloud (Difference) ?		abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded	abrogates autophagy carried connections endoplasmic er extent hct116 interest ire1 microarray nbr1 nix p62 particular perk regulates reticulum sqstm1 stages still stress subjected transcriptional transmembrane unclear unfolded upr upregulation
Tagcloud (Intersection) ?