CARD10 and BCL10

Number of citations of the paper that reports this interaction (PMID 11387339)
36

Data Source:
HPRD (in vitro, in vivo)

		CARD10	BCL10
Gene Name		caspase recruitment domain family, member 10	B-cell CLL/lymphoma 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm CBM Complex	Immunological Synapse Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Plasma Membrane CBM Complex T Cell Receptor Complex Protein Complex Membrane Raft Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Receptor Signaling Complex Scaffold Activity	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Kinase B Binding Protein Self-association NF-kappaB Binding
	Biological Process	Protein Complex Assembly Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process	B Cell Apoptotic Process Neural Tube Closure Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Response To Food Positive Regulation Of Mast Cell Cytokine Production Fc-epsilon Receptor Signaling Pathway Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Protein Homooligomerization T Cell Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Optic disc parameters ( 21307088)
Protein-Protein Interactions		4 interactors: ATXN7 BCL10 IKBKG KLHL12	35 interactors: AKT1 ATM BIRC3 C9orf89 CARD10 CARD11 CARD14 CARD9 CASP9 CDK9 CHUK IKBKB IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NLRC4 PELI2 PRRG4 RIPK2 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 UBC UBE2N UBE2V2 USHBP1
Entrez ID		29775	8915
HPRD ID		06233	04625
Ensembl ID		ENSG00000100065	ENSG00000142867
Uniprot IDs		Q8NC81 Q9BWT7	O95999
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Mast Cell Cytokine Production Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Negative Regulation Of Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Innate Immune Response Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Interleukin-6 Production Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Establishment Of Organelle Localization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Cytokine Production B Cell Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Apoptotic Process Organelle Localization Regulation Of Interleukin-8 Biosynthetic Process Immune Response-regulating Signaling Pathway T Cell Apoptotic Process Regulation Of Cytokine Production Regulation Of B Cell Apoptotic Process Histone Deubiquitination COPII Vesicle Coating Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Budding	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Signaling Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response Positive Regulation Of Immune Response Toll-like Receptor 9 Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Signal Transduction Immune Response Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2	adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2	adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Intersection) ?