CARD10 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CARD10	PNKP
Description		caspase recruitment domain family member 10	polynucleotide kinase 3'-phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm CBM Complex	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein-containing Complex Assembly Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Localization To Nucleus	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Autoimmune hepatitis type-1 ( 24768677) Low vWF levels ( 26486471) Optic disc area ( 21307088 25631615 28073927 31798171) Optic disc size ( 31809533) Refractive error ( 32231278) Vertical cup-disc ratio ( 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		105 interacting genes: ATXN7 BAHD1 BCL10 BCL6B C8orf48 CARD9 CATSPER1 CBX8 CCDC116 CCDC187 CDC37 CEP95 CHIC2 CNNM3 CWF19L2 CXCL16 CYSRT1 DHX57 DOCK2 DRC4 DUSP26 FAM47B FOXD4L3 GADD45GIP1 GFAP GIPC1 GPATCH2L GSE1 GSTP1 HBZ HOXB9 IKBKG IL16 JOSD1 KANK2 KDM1A KEAP1 KLHL12 KRT75 KRTAP10-8 KRTAP12-3 KRTAP26-1 KRTAP9-2 KRTAP9-3 LENG1 MAGOHB METTL17 MITD1 MYPOP NME7 OLIG3 PIBF1 PKP1 PNKP PRDM14 PRPF18 PRPF3 PRR35 PTCD1 PTGDS RIN1 SCNM1 SEMA3B SPATA18 SPMIP2 TBC1D22B TBC1D26 TFAP2D TMEM43 TRIM27 TRIM41 USP54 UTP14C ZBTB26 ZFP1 ZNF10 ZNF12 ZNF165 ZNF180 ZNF202 ZNF223 ZNF239 ZNF250 ZNF285 ZNF286A ZNF32 ZNF329 ZNF366 ZNF414 ZNF415 ZNF439 ZNF440 ZNF524 ZNF552 ZNF559 ZNF564 ZNF575 ZNF581 ZNF587 ZNF613 ZNF670 ZNF775 ZNF80 ZNF837 ZSCAN25	50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		29775	11284
HPRD ID		06233	09284
Ensembl ID		ENSG00000100065	ENSG00000039650
Uniprot IDs		Q9BWT7	Q96T60
PDB IDs			2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA Binding Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein Binding Regulation Of Metabolic Process Nucleus Intermediate Filament Metal Ion Binding DNA-binding Transcription Factor Activity Keratin Filament RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding CBM Complex	Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining
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